دورية أكاديمية
أعرض في EDS

Mid1 aggravates hepatic ischemia-reperfusion injury by inducing immune cell infiltration.

التفاصيل البيبلوغرافية
العنوان: Mid1 aggravates hepatic ischemia-reperfusion injury by inducing immune cell infiltration.
المؤلفون: Li J; Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China., Jin C; Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China., Li Y; Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China., Liu H; Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China.
المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Jul 31; Vol. 38 (14), pp. e23823.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley
Original Publication: [Bethesda, Md.] : The Federation, [c1987-
مواضيع طبية MeSH: Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Reperfusion Injury*/immunology , Mice, Inbred C57BL* , Kupffer Cells*/metabolism , Liver*/pathology , Liver*/metabolism, Animals ; Mice ; Male ; Neutrophil Infiltration ; Cytokines/metabolism ; Transcription Factors/metabolism ; Transcription Factors/genetics ; NF-kappa B/metabolism ; Apoptosis ; Inflammation/metabolism ; Inflammation/pathology ; Signal Transduction
مستخلص: Hepatic ischemia-reperfusion injury (HIRI) represents a major risk factor in liver transplantation and resection surgeries. Kupffer cells (KCs) produce proinflammatory cytokines and lead to hepatic neutrophil infiltration in the liver, which is one of the leading causes of HIRI. Mid1 is involved in immune infiltration, but the role of Mid1 remains poorly understood. Herin, our study aimed to investigate the effect of Mid1 on HIRI progression. Male C57BL/6 mice aged 6 weeks were used for the HIRI model established. The function of Mid1 on liver injury and hepatic inflammation was evaluated. In vitro, KCs were used to investigate the function and mechanism of Mid1 in modulating KC inflammation upon lipopolysaccharide (LPS) stimulation. We found that Mid1 expression was up-regulated upon HIRI. Mid1 inhibition alleviated liver damage, as evidenced by neutrophil infiltration, intrahepatic inflammation, and hepatocyte apoptosis. In vitro experiments further revealed that Mid1 knockdown reduced the secretion of proinflammatory cytokines and chemokines in KCs. Moreover, silenced-Mid1 suppressed proinflammatory responses by the inhibition of NF-κB, JNK, and p38 signaling pathways. Taken together, Mid1 contributes to HIRI via regulating the proinflammatory response of KCs and inducing neutrophil infiltration. Targeting Mid1 may be a promising strategy to protect against HIRI.
(© 2024 Federation of American Societies for Experimental Biology.)
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فهرسة مساهمة: Keywords: Kupffer cells; Mid1; hepatic ischemia–reperfusion injury; neutrophils
المشرفين على المادة: 0 (Cytokines)
0 (Transcription Factors)
0 (NF-kappa B)
تواريخ الأحداث: Date Created: 20240715 Date Completed: 20240715 Latest Revision: 20240715
رمز التحديث: 20240715
DOI: 10.1096/fj.202400843R
PMID: 39008003
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-6860
DOI:10.1096/fj.202400843R