| المؤلفون: |
Kathia MM; Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada., Duplea SG; Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Bommarito JC; Human Health & Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Hinks A; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Leake E; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Shannon J; Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, Canada., Pitman J; Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, Canada., Khangura PK; Human Health & Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Coates AM; Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Slysz JT; Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Katerberg C; Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., McCarthy DG; Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Beedie T; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Malcolm R; Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Witton LA; Northern Neurosciences, Orillia, ON, Canada., Connolly B; Department of Medicine, McMaster University, Hamilton, ON, Canada., Burr JF; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Vallis LA; Human Health & Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Power GA; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Millar PJ; Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada. |
| مستخلص: |
Exercise training is recommended to improve quality of life in those living with Parkinson's Disease (PD); however, the optimal prescription to improve cardiorespiratory fitness and disease-related motor symptoms remains unknown. Twenty-nine participants with PD were randomly allocated to either 10-weeks of high-intensity interval training (HIIT) (n=15; 6 female) or moderate-intensity continuous training (MICT) (n=14; 5 female). The primary outcome was the change in maximal oxygen consumption (VO 2peak ). Secondary outcomes included changes in the Unified Parkinson's Disease Rating Scale (UPDRS) Part III motor score, Parkinson's Disease Fatigue Scale (PFS-16), resting and exercise cardiovascular measures, gait, balance, and knee extensor strength and fatigability. Exercise training increased VO 2peak (main effect of time, P <0.01), with a clinically-meaningful difference in the change following HIIT vs. MICT (∆3.7±3.7 vs. 1.7±3.2 ml∙kg -1 ∙min -1 , P =0.099). The UPDRS motor score improved over time ( P <0.001) but without any differences between HIIT vs. MICT (∆-9.7±1.3 vs. -8.4±1.4, P =0.51). Self-reported subjective fatigue (PFS-16) decreased over time (P<0.01) but was similar between HIIT and MICT groups ( P =0.6). Gait, balance, blood pressure, and heart rate were unchanged with training (all P >0.09). Knee extensor strength increased over time ( P =0.03) but did not differ between HIIT vs. MICT (∆8.2±5.9 vs. 11.7±6.2 Nm, P =0.69). HIIT alone increased muscular endurance of the knee extensors during an isotonic task to failure ( P =0.04). In participants with PD, HIIT and MICT both increased VO 2peak and led to improvements in motor symptoms and perceived fatigue; HIIT may offer the potential for larger changes in VO 2peak and reduced knee extensor fatigability. |
