دورية أكاديمية
MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses.
العنوان: | MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses. |
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المؤلفون: | Karakus U; Institute of Medical Virology, University of Zurich, Zurich, Switzerland.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sempere Borau M; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Martínez-Barragán P; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., von Kempis J; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Yildiz S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Arroyo-Fernández LM; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Pohl MO; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Steiger JA; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Glas I; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Hunziker A; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stertz S; Institute of Medical Virology, University of Zurich, Zurich, Switzerland. stertz.silke@virology.uzh.ch. |
المصدر: | Nature microbiology [Nat Microbiol] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Publishing Group, [2016]- |
مستخلص: | Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic acid on host glycans as receptor, whereas some bat IAV require MHC class II complexes for cell entry. It is unknown how this difference evolved and whether dual receptor specificity is possible. Here we show that human H2N2 IAV and related avian H2N2 possess dual receptor specificity in cell lines and primary human airway cultures. Using sialylation-deficient cells, we reveal that entry via MHC class II is independent of sialic acid. We find that MHC class II from humans, pigs, ducks, swans and chickens but not bats can mediate H2 IAV entry and that this is conserved in Eurasian avian H2. Our results demonstrate that IAV can possess dual receptor specificity for sialic acid and MHC class II, and suggest a role for MHC class II-dependent entry in zoonotic IAV infections. (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.) |
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معلومات مُعتمدة: | 310030_204166 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation); P500PB_206818 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation); P400PB_199292 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation); 18C190 Novartis Stiftung für Medizinisch-Biologische Forschung (Novartis Foundation for Medical-Biological Research); 75N93021C00014 United States AI NIAID NIH HHS; U19AI142733 U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID); U19AI168631 U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) |
تواريخ الأحداث: | Date Created: 20240715 Latest Revision: 20240715 |
رمز التحديث: | 20240716 |
DOI: | 10.1038/s41564-024-01771-1 |
PMID: | 39009691 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2058-5276 |
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DOI: | 10.1038/s41564-024-01771-1 |