دورية أكاديمية
أعرض في EDS

Association of cord blood Ang-1 and sCD105 levels with bronchopulmonary dysplasia in preterm infants.

التفاصيل البيبلوغرافية
العنوان: Association of cord blood Ang-1 and sCD105 levels with bronchopulmonary dysplasia in preterm infants.
المؤلفون: Yang J; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China., Wang Y; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China., Wu Y; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China., Fan H; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China., Jin O; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China., Tang L; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China., Tung TH; Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang, 317000, China., Zhang M; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China. meixian0116@163.com.; Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang, 317000, China. meixian0116@163.com., Wang L; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China. wanglz@enzemed.com.; Department of Pediatrics, Taizhou Enze Medical Center (Group), Enze Hospital, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, 318050, China. wanglz@enzemed.com.
المصدر: BMC pediatrics [BMC Pediatr] 2024 Jul 15; Vol. 24 (1), pp. 451. Date of Electronic Publication: 2024 Jul 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967804 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2431 (Electronic) Linking ISSN: 14712431 NLM ISO Abbreviation: BMC Pediatr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Bronchopulmonary Dysplasia*/blood , Endoglin*/blood , Infant, Premature*/blood , Fetal Blood*/chemistry , Fetal Blood*/metabolism , Angiopoietin-1*/blood, Humans ; Infant, Newborn ; Female ; Male ; Biomarkers/blood ; Logistic Models
مستخلص: Background: To investigate the relationship between cord blood levels of Angiopoietin-1 (Ang-1) and S-endoglin (sCD105) and bronchopulmonary dysplasia (BPD) in preterm infants.
Methods: Sixty-one preterm infants admitted to the neonatal intensive care unit of the study hospital between July 2021 and September 2022 were included. Cord blood was collected after the birth of premature infants. Ang-1 and sCD105 levels were quantified using the vascular endothelial growth factor enzyme-linked immunosorbent assay. Preterm infants were divided into BPD and non-BPD groups, and differences in Ang-1 and sCD105 levels between the two groups were compared. A binary logistic model was used to assess the association between low and high levels Ang-1 and BPD in preterm infants.
Results: In the study, there were 20 preterm infants with BPD (32.8%) and 41 preterm infants with non-BPD (67.2%). Ang-1 concentration levels were lower in the BPD group than in the non-BPD group (7105.43 (5617.01-8523.00) pg/ml vs. 10488.03 (7946.19-15962.77) pg/ml, P = 0.027). However, the sCD105 concentration levels were not significantly different between the BPD and non-BPD groups (P = 0.246). A median Ang-1 concentration of 8800.40 pg/ml was calculated. Logistic regression analysis showed that after adjusting for gestational age, birth weight, and maternal prenatal steroid hormone application, the odds ratio (OR) was 8.577 for the risk of BPD in preterm infants with Ang-1 concentrations of ≤ 8800.40 pg/ml compared to those with Ang-1 concentrations of > 8800.40 pg/ml (OR: 8.577, 95% confidence interval: 1.265-58.155, P = 0.028).
Conclusion: Our study indicated that Ang-1 levels in the cord blood of preterm infants may be associated the risk of BPD. In the future, we will continue to conduct study with large samples.
(© 2024. The Author(s).)
References: Neonatology. 2014;106(1):55-61. (PMID: 24818792)
Am J Respir Crit Care Med. 2019 Sep 15;200(6):659-660. (PMID: 31091958)
Biol Neonate. 2006;89(4):313-22. (PMID: 16770071)
Am J Respir Crit Care Med. 2015 Jan 1;191(1):87-95. (PMID: 25389562)
Curr Opin Pediatr. 2014 Jun;26(3):306-14. (PMID: 24739494)
J Clin Res Pediatr Endocrinol. 2016 Sep 1;8(3):313-20. (PMID: 27097763)
Cytokine Growth Factor Rev. 1997 Mar;8(1):21-43. (PMID: 9174661)
J Trop Pediatr. 2011 Oct;57(5):385-8. (PMID: 21131270)
Heart Vessels. 2012 Jul;27(4):344-51. (PMID: 21667051)
JAMA. 2015 Sep 8;314(10):1039-51. (PMID: 26348753)
Mol Cell Pediatr. 2016 Dec;3(1):23. (PMID: 27357257)
Pediatr Res. 2022 May;91(6):1405-1415. (PMID: 33980990)
Histol Histopathol. 2010 Mar;25(3):387-96. (PMID: 20054809)
Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L585-95. (PMID: 12169578)
Zhonghua Er Ke Za Zhi. 2019 Dec 2;57(12):934-942. (PMID: 31795560)
Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9. (PMID: 11401896)
J Pediatr. 2018 Jun;197:300-308. (PMID: 29551318)
J Perinatol. 2020 Nov;40(11):1634-1643. (PMID: 32811975)
Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L600-7. (PMID: 10956636)
J Perinatol. 2015 May;35(5):313-321. (PMID: 25811285)
Neonatology. 2007;91(4):291-7. (PMID: 17575472)
Sci Rep. 2020 Feb 20;10(1):3043. (PMID: 32080296)
Pregnancy Hypertens. 2018 Jul;13:148-153. (PMID: 30177044)
Biochem Biophys Res Commun. 2009 Jun 12;383(4):386-91. (PMID: 19268655)
Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L893-905. (PMID: 24213917)
Cell. 1996 Dec 27;87(7):1161-9. (PMID: 8980223)
Exp Ther Med. 2018 Dec;16(6):4315-4321. (PMID: 30542380)
Respir Med. 2017 Nov;132:170-177. (PMID: 29229093)
فهرسة مساهمة: Keywords: Ang-1; Bronchopulmonary dysplasia; Early prediction; Preterm infants; sCD105
المشرفين على المادة: 0 (Endoglin)
0 (ENG protein, human)
0 (Angiopoietin-1)
0 (Biomarkers)
0 (ANGPT1 protein, human)
تواريخ الأحداث: Date Created: 20240715 Date Completed: 20240715 Latest Revision: 20240718
رمز التحديث: 20240718
مُعرف محوري في PubMed: PMC11247901
DOI: 10.1186/s12887-024-04932-7
PMID: 39010003
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2431
DOI:10.1186/s12887-024-04932-7