دورية أكاديمية
أعرض في EDS

COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study.

التفاصيل البيبلوغرافية
العنوان: COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study.
المؤلفون: Fang C; Peking University Fifth School of Clinical Medicine, Beijing, 100730, China.; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China., Li A; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China., Li Y; Peking University Fifth School of Clinical Medicine, Beijing, 100730, China. lymyl@263.net.; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China. lymyl@263.net.
المصدر: BMC pulmonary medicine [BMC Pulm Med] 2024 Jul 15; Vol. 24 (1), pp. 341. Date of Electronic Publication: 2024 Jul 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001]-
مواضيع طبية MeSH: Pulmonary Disease, Chronic Obstructive*/genetics , Pulmonary Disease, Chronic Obstructive*/physiopathology , Mendelian Randomization Analysis*, Humans ; Forced Expiratory Volume ; Vital Capacity ; Genome-Wide Association Study ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/physiopathology ; Cerebral Cortex/pathology ; Male ; Polymorphism, Single Nucleotide ; Case-Control Studies ; Lung/physiopathology
مستخلص: Chronic obstructive pulmonary disease (COPD) has been associated with alterations in the brain cortical structure. Nonetheless, the causality between COPD and brain cortical structure has not been determined. In the present study, we used Mendelian randomization (MR) analysis to explore the causal effects of genetic predicated COPD on brain cortical structure, namely cortical surface area (SA) and cortical thickness (TH). Genetic association summary data for COPD were obtained from the FinnGen consortium (N = 358,369; Ncase = 20,066). PRISm summary genetic data were retrieved from a case-control GWAS conducted in the UK Biobank (N = 296,282). Lung function indices, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC, were extracted from a meta-analysis of the UK Biobank and SpiroMeta consortium (N = 400,102). Brain cortical structure data were obtained from the ENIGMA consortium (N = 51,665). Inverse-variance weighted (IVW) method was used as the primary analysis, and a series of sensitivity tests were exploited to evaluate the heterogeneity and pleiotropy of our results. The results identified potential causal effects of COPD on several brain cortical specifications, including pars orbitalis, cuneus and inferior parietal gyrus. Furthermore, genetic predicated lung function index (FEV1, FVC and FEV1/FVC), as well as PRISm, also has causal effects on brain cortical structure. According to our results, a total of 15 functional specifications were influenced by lung function index and PRISm. These findings contribute to understanding the causal effects of COPD and lung function to brain cortical structure.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 2023YFC3605000 Comprehensive management technology and demonstration research on coexistence of multiple diseases in the elderly; 2023YFC3605000 Comprehensive management technology and demonstration research on coexistence of multiple diseases in the elderly; 2023YFC3605000 Comprehensive management technology and demonstration research on coexistence of multiple diseases in the elderly
فهرسة مساهمة: Keywords: Brain cortical structural; Chronic obstructive pulmonary disease; Lung function; Mendelian randomization
تواريخ الأحداث: Date Created: 20240715 Date Completed: 20240716 Latest Revision: 20240718
رمز التحديث: 20240718
مُعرف محوري في PubMed: PMC11251327
DOI: 10.1186/s12890-024-03150-2
PMID: 39010041
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2466
DOI:10.1186/s12890-024-03150-2