دورية أكاديمية
أعرض في EDS

Efficacy of iron supplementation on physical capacity in non-anaemic iron-deficient individuals: protocol for an individual patient data meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Efficacy of iron supplementation on physical capacity in non-anaemic iron-deficient individuals: protocol for an individual patient data meta-analysis.
المؤلفون: Dugan C; School of Human Sciences, University of Western Australia, Perth, Australia. cory.dugan@research.uwa.edu.au., Peeling P; School of Human Sciences, University of Western Australia, Perth, Australia., Burden R; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK., Richards T; Division of Surgery, University of Western Australia, Perth, Australia.
المصدر: Systematic reviews [Syst Rev] 2024 Jul 15; Vol. 13 (1), pp. 182. Date of Electronic Publication: 2024 Jul 15.
نوع المنشور: Journal Article; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101580575 Publication Model: Electronic Cited Medium: Internet ISSN: 2046-4053 (Electronic) Linking ISSN: 20464053 NLM ISO Abbreviation: Syst Rev Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Dietary Supplements* , Iron*/therapeutic use , Iron Deficiencies*, Humans ; Systematic Reviews as Topic ; Quality of Life ; Meta-Analysis as Topic ; Fatigue/drug therapy ; Anemia, Iron-Deficiency/drug therapy
مستخلص: Background: A deficiency in iron stores is associated with various adverse health complications, which, if left untreated, can progress to states of anaemia, whereby there is significant detriment to an individual's work capacity and quality of life due to compromised erythropoiesis. The most common methods employed to treat an iron deficiency include oral iron supplementation and, in persistent and/or unresponsive cases, intravenous iron therapy. The efficacy of these treatments, particularly in states of iron deficiency without anaemia, is equivocal. Indeed, both randomised control trials and aggregate data meta-analyses have produced conflicting evidence. Therefore, this study aims to assess the efficacy of both oral and intravenous iron supplementation on physical capacity, quality of life, and fatigue scores in iron-deficient non-anaemic individuals using individual patient data (IPD) meta-analysis techniques.
Methods: All potential studies, irrespective of design, will be sourced through systematic searches on the following databases: Cochrane Central Register of Controlled Trials, MEDLINE Ovid, Embase Ovid, Web of Science: Science Citation Index Expanded, Web of Science: Conference Proceedings Citation Index-Science, ClinicalTrials.gov, and World Health Organization (WHO) International Clinical Trials Registry Platform. Individual patient data from all available trials will be included and subsequently analysed in a two-stage approach. Predetermined subgroup and sensitivity analyses will be employed to further explain results.
Discussion: The significance of this IPD meta-analysis is one of consolidating a clear consensus to better inform iron-deficient individuals of the physiological response associated with iron supplementation. The IPD approach, to the best of our knowledge, is novel for this research topic. As such, the findings will significantly contribute to the current body of evidence.
Systematic Review Registration: PROSPERO CRD42020191739.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Individual patient data; Iron deficiency; Iron supplementation; Non-anaemia; Physical capacity; Quality of life
المشرفين على المادة: E1UOL152H7 (Iron)
تواريخ الأحداث: Date Created: 20240715 Date Completed: 20240716 Latest Revision: 20240717
رمز التحديث: 20240717
مُعرف محوري في PubMed: PMC11247796
DOI: 10.1186/s13643-024-02559-4
PMID: 39010146
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-4053
DOI:10.1186/s13643-024-02559-4