دورية أكاديمية
أعرض في EDS

Microproteins/micropeptides dysregulation contributes to cancer progression and development: A mechanistic review.

التفاصيل البيبلوغرافية
العنوان: Microproteins/micropeptides dysregulation contributes to cancer progression and development: A mechanistic review.
المؤلفون: Rodrigues P; Department of Computer Engineering, College of Computer Science, King Khalid University, Al-Faraa, Asir-Abha, Kingdom of Saudi Arabia., Bangali H; Department of Computer Engineering, College of Computer Science, King Khalid University, Al-Faraa, Saudi Arabia., Ali E; College of Chemistry, Al-Zahraa University for Women, Karbala, Iraq., Sharma MK; Chaudhary Charan Singh University, Meerut, Uttar Pradesh, India., Abdullaev B; Department of Biotechnology, New Uzbekistan University, Tashkent, Uzbekistan., Alkhafaji AT; Cardiology Department, College of Medicine, Al-Ayen University, Thi-Qar, Iraq., Deorari MM; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India., Zabibah RS; College of Technical Engineering, The Islamic University, Najaf, Iraq.; College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq., Haslany A; College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.
المصدر: Cell biology international [Cell Biol Int] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.
Publication Model: Ahead of Print
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Chichester Country of Publication: England NLM ID: 9307129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8355 (Electronic) Linking ISSN: 10656995 NLM ISO Abbreviation: Cell Biol Int Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : John Wiley & Sons Chichester :
Original Publication: London, UK : Published for the International Federation for Cell Biology by Academic Press, c1993-
مستخلص: Microproteins, known as micropeptides, are small protein molecules encoded by short open reading frames. These recently identified molecules have been proven to be an essential part of the human proteome that participates in multiple processes, such as DNA repair, mitochondrial respiration, and regulating different signaling pathways. A growing body of studies has evidenced that microproteins exhibit dysregulated expression levels in various malignancies and contribute to tumor progression. It has been reported that microproteins interact with many proteins, such as enzymes (e.g., adenosine triphosphate synthase) and signal transducers (e.g., c-Jun), and regulate malignant cell metabolism, proliferation, and metastasis. Moreover, microproteins have been found to play a significant role in multidrug resistance in vitro and in vivo by their activity in DNA repair pathways. Considering that, this review intended to summarize the roles of microproteins in different aspects of tumorigenesis with diagnostic and therapeutic perspectives.
(© 2024 International Federation for Cell Biology.)
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معلومات مُعتمدة: RGP2/403/45 Deanship of Scientific Research at King Khalid University, Abha, Saudi Arabia
فهرسة مساهمة: Keywords: cancer; drug resistance; metastasis; micropeptide; microprotein
تواريخ الأحداث: Date Created: 20240716 Latest Revision: 20240716
رمز التحديث: 20240716
DOI: 10.1002/cbin.12219
PMID: 39010637
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-8355
DOI:10.1002/cbin.12219