دورية أكاديمية
Medulla oblongata and NCCs are central defenders against Streptococcus agalactiae infection of the tilapia brain.
| العنوان: | Medulla oblongata and NCCs are central defenders against Streptococcus agalactiae infection of the tilapia brain. |
|---|---|
| المؤلفون: | Hou X; Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China., Li Q; College of Fishery, Guangdong Ocean University, Zhanjiang, China. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Jul 01; Vol. 15, pp. 1442906. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Streptococcal Infections*/immunology , Streptococcal Infections*/microbiology , Streptococcus agalactiae*/immunology , Streptococcus agalactiae*/physiology , Fish Diseases*/immunology , Fish Diseases*/microbiology , Medulla Oblongata*/immunology, Animals ; Brain/immunology ; Brain/microbiology ; Tilapia/immunology ; Tilapia/microbiology ; Cichlids/immunology ; Cichlids/microbiology |
| مستخلص: | Various types of professional immune cells first emerge in fish and likely represent the primordial form and functions. Recent advancements revealed the direct connection between the central nervous system and the immune system in the mammalian brain. However, the specifics of brain-immune networks in the fish and the underlying mechanisms of teleost's brain against pathogen infection have not been fully elucidated. In this study, we investigated the distribution of markers representing cerebral cells associated with protection and professional lymphocytes in the seven major components of the Nile tilapia brain through RNA-Seq assay and observed the most dominant abundance in the medulla oblongata. The subsequent challenge test revealed the non-specific cytotoxic cells (NCCs) exhibited the strongest response against streptococcal infection of the brain. The presence of NCCs in the brain was then confirmed using immunofluorescence and the cytotoxic effects usually induced by NCCs under infection were determined as well. Collectively, these findings contribute significantly to comprehending the mechanism of fish neuroimmune interaction and enhancing our understanding of its evolutionary development. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hou and Li.) |
| References: | Nat Rev Drug Discov. 2010 Sep;9(9):703-18. (PMID: 20811382) Trends Cogn Sci. 2014 Sep;18(9):465-71. (PMID: 24815200) Front Immunol. 2021 Dec 28;12:783196. (PMID: 35027916) Nat Rev Neurosci. 2018 Nov;19(11):655-671. (PMID: 30310148) Cell. 2021 Feb 18;184(4):1000-1016.e27. (PMID: 33508229) J Bacteriol. 2012 Sep;194(18):5132-3. (PMID: 22933761) Signal Transduct Target Ther. 2023 May 25;8(1):217. (PMID: 37231000) Nat Immunol. 2021 Sep;22(9):1083-1092. (PMID: 34429552) Sci Adv. 2023 Feb 22;9(8):eade9909. (PMID: 36812331) Fish Shellfish Immunol. 2023 Aug;139:108923. (PMID: 37394017) Curr Biol. 2019 Jan 21;29(2):229-241.e6. (PMID: 30612902) Front Cell Neurosci. 2022 Jun 13;16:902372. (PMID: 35769325) Epilepsia Open. 2019 Feb 14;4(1):30-39. (PMID: 30868113) Trends Immunol. 2015 Oct;36(10):569-577. (PMID: 26431936) Nat Rev Neurol. 2023 Jul;19(7):395-409. (PMID: 37308616) Mol Omics. 2019 Jun 1;15(3):233-246. (PMID: 31098608) Int J Mol Sci. 2019 Nov 28;20(23):. (PMID: 31795299) Nat Neurosci. 2018 Jun;21(6):779-786. (PMID: 29735982) Immunol Lett. 2012 Nov-Dec;148(1):23-33. (PMID: 22902399) Front Immunol. 2022 Jul 28;13:944388. (PMID: 35967362) Animals (Basel). 2020 Nov 20;10(11):. (PMID: 33233716) Microsc Res Tech. 2020 Aug;83(8):877-888. (PMID: 32243694) J Clin Invest. 2014 Mar;124(3):1228-41. (PMID: 24569378) Genomics. 2020 Nov;112(6):5170-5179. (PMID: 32971213) Gene. 2013 Sep 15;527(1):183-92. (PMID: 23792389) Science. 2023 Apr 7;380(6640):eabo7649. (PMID: 37023203) Nat Commun. 2021 Oct 8;12(1):5916. (PMID: 34625548) Sci Adv. 2020 Nov 18;6(47):. (PMID: 33208372) Mol Immunol. 2021 May;133:184-193. (PMID: 33744653) Nat Rev Immunol. 2018 Feb;18(2):83-84. (PMID: 29279610) Nature. 2015 Jul 16;523(7560):337-41. (PMID: 26030524) Curr Biol. 2009 Aug 25;19(16):R678-82. (PMID: 19706273) J Neuroinflammation. 2022 Jun 28;19(1):170. (PMID: 35765004) Nat Neurosci. 2017 Feb;20(2):136-144. (PMID: 28092660) Fish Shellfish Immunol. 2022 Dec;131:218-228. (PMID: 36198379) Fish Shellfish Immunol. 2020 Sep;104:579-586. (PMID: 32610151) Nat Rev Neurol. 2022 Mar;18(3):158-172. (PMID: 35115728) Nat Rev Immunol. 2011 Sep 23;11(10):658-71. (PMID: 21941294) Fish Shellfish Immunol. 2021 Aug;115:95-103. (PMID: 34058353) J Fish Dis. 2022 Oct;45(10):1451-1462. (PMID: 35758189) Int J Mol Sci. 2022 Nov 28;23(23):. (PMID: 36499231) Sci Adv. 2023 Nov 3;9(44):eadh7693. (PMID: 37910612) Front Mol Neurosci. 2019 Mar 06;12:57. (PMID: 30894799) Fish Shellfish Immunol. 2022 Apr;123:218-228. (PMID: 35257891) Nat Neurosci. 2020 Oct;23(10):1297-1306. (PMID: 32895565) PLoS Pathog. 2021 Jun 29;17(6):e1009665. (PMID: 34185811) Front Neurosci. 2014 Nov 10;8:364. (PMID: 25426018) |
| فهرسة مساهمة: | Keywords: NCCs; Nile tilapia; Streptococcus agalactiae; immune response; medulla oblongata |
| تواريخ الأحداث: | Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| مُعرف محوري في PubMed: | PMC11246860 |
| DOI: | 10.3389/fimmu.2024.1442906 |
| PMID: | 39011038 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
|---|---|
| DOI: | 10.3389/fimmu.2024.1442906 |