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Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice.

التفاصيل البيبلوغرافية
العنوان: Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice.
المؤلفون: Mun SK; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Jang CJ; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Jo S; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Park SH; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Sim HB; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Ramos SC; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Kim H; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Choi YJ; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Park DH; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea., Park KW; R&D team, Suncheon Research Center for Bio Health Care, Suncheon, Republic of Korea., Jeong BG; R&D team, Suncheon Research Center for Bio Health Care, Suncheon, Republic of Korea., Kim DH; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea.; CCRIPO Inc., Daejeon, Republic of Korea., Kang KY; R&D team, Suncheon Research Center for Bio Health Care, Suncheon, Republic of Korea., Kim JJ; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea.
المصدر: Animal cells and systems [Anim Cells Syst (Seoul)] 2024 Jul 13; Vol. 28 (1), pp. 340-352. Date of Electronic Publication: 2024 Jul 13 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101478641 Publication Model: eCollection Cited Medium: Print ISSN: 1976-8354 (Print) Linking ISSN: 19768354 NLM ISO Abbreviation: Anim Cells Syst (Seoul) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2010- : Abingdon, Oxfordshire : Taylor & Francis
Original Publication: Seoul, Korea : Zoological Society of Korea, c2005-
مستخلص: Preventing disease and maintaining the health of the elderly are crucial goals for an aging population, with obesity and immune function restoration being of paramount importance. Obesity, particularly visceral obesity characterized by excessive fat accumulation around the abdominal organs, is linked to chronic conditions such as diabetes, hypertension, cardiovascular diseases, and immune dysfunction. Globally, obesity is considered a disease, prompting significant research interest in its treatment. Therefore, it is essential to explore potential therapeutic and preventive strategies to address obesity and the decline in immune function brought about by aging. Tenebrio molitor larvae (TML), commonly known as 'mealworms,' are rich in unsaturated fatty acids, including oleic and linoleic acids, and essential amino acids, such as isoleucine and tyrosine. In this study, we aimed to investigate the effects of the consumption of TML oil and mealworm fermented extract (MWF-1) on obesity and immunological changes in aged obese mice. Our data showed reduced body fat in 23-week-old C57BL/6 mice fed processed TML products for 6 weeks. Additionally, the characteristically high levels of serum triglycerides decreased by treating with TML oil. The immune responsiveness results confirmed an increase in B cells by treating with MWF-1, while cytokine levels (interferon-gamma, tumor necrosis factor-alpha, interleukin-2, and -6) were restored to levels similar to young mice. These results suggest that TML oil and MWF-1 are promising dietary supplements for addressing obesity and restoring immune function.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
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فهرسة مساهمة: Keywords: Aging; Tenebrio molitor; immunomodulatory effects; insect consumption; obesity
تواريخ الأحداث: Date Created: 20240716 Latest Revision: 20240717
رمز التحديث: 20240717
مُعرف محوري في PubMed: PMC11249154
DOI: 10.1080/19768354.2024.2374547
PMID: 39011371
قاعدة البيانات: MEDLINE
الوصف
تدمد:1976-8354
DOI:10.1080/19768354.2024.2374547