دورية أكاديمية
Polymeric nanoparticles produced by electrohydrodynamic atomisation for the passive delivery of imatinib.
| العنوان: | Polymeric nanoparticles produced by electrohydrodynamic atomisation for the passive delivery of imatinib. |
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| المؤلفون: | Tsilova SL; School of Pharmacy, University College London, London, United Kingdom., Schreiber BE; National Pulmonary Hypertension Service, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, United Kingdom., Lever R; School of Pharmacy, University College London, London, United Kingdom., Parhizkar M; School of Pharmacy, University College London, London, United Kingdom. Electronic address: maryam.parhizkar@ucl.ac.uk. |
| المصدر: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2024 Sep; Vol. 202, pp. 114412. Date of Electronic Publication: 2024 Jul 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991- |
| مواضيع طبية MeSH: | Imatinib Mesylate*/administration & dosage , Imatinib Mesylate*/pharmacology , Imatinib Mesylate*/pharmacokinetics , Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry , Nanoparticles*/chemistry , Particle Size* , Cell Survival*/drug effects , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacology , Drug Carriers*/chemistry, Humans ; A549 Cells ; Drug Delivery Systems/methods ; Lactic Acid/chemistry ; Drug Liberation ; Polyglycolic Acid/chemistry ; Polymers/chemistry ; Cell Line, Tumor |
| مستخلص: | Imatinib is a chemotherapeutic agent known to cause severe side effects when administrated systemically. Encapsulating imatinib in co-polymer poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) offers a targeted drug delivery. In this work, PLGA 50:50 and PLGA 75:25 NPs encapsulated imatinib using the electrohydrodynamic atomisation technique. All particles generated were spherical with a smooth surface with a size distribution of 455±115 nm (PLGA 50:50) and 363±147 nm (PLGA 75:25). Encapsulation of imatinib was shown to be higher than 75 % and was shown to increase the zeta potential of the loaded NPs. The release of imatinib showed an initial burst in the first 12 h, followed by different sustained releases with up to 70 %. Both types of imatinib-loaded NPs' effect on cell viability and their cellular uptake were also studied on A549 cells, and the antiproliferative effect was comparable to that of cells treated with free drugs. Finally, Rhodamine-B-loaded NP-treated cells demonstrated the cellular uptake of NPs. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antiproliferative; Controlled Release; Electrohydrodynamic atomisation; Imatinib; Nanoparticles; PLGA |
| المشرفين على المادة: | 8A1O1M485B (Imatinib Mesylate) 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) 0 (Antineoplastic Agents) 0 (Drug Carriers) 33X04XA5AT (Lactic Acid) 26009-03-0 (Polyglycolic Acid) 0 (Polymers) |
| تواريخ الأحداث: | Date Created: 20240716 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1016/j.ejpb.2024.114412 |
| PMID: | 39013491 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3441 |
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| DOI: | 10.1016/j.ejpb.2024.114412 |