دورية أكاديمية
The association between blood urea nitrogen to albumin ratio and the 28 day mortality in tuberculosis patients complicated by sepsis.
العنوان: | The association between blood urea nitrogen to albumin ratio and the 28 day mortality in tuberculosis patients complicated by sepsis. |
---|---|
المؤلفون: | Cui K; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China., Feng S; Ultrasonic Medicine, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Mao Y; Intensive Care Unit, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Luo H; Intensive Care Unit, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Yang J; Intensive Care Unit, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Xu R; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China., Bai L; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China. pangbailang@163.com. |
المصدر: | Scientific reports [Sci Rep] 2024 Jul 16; Vol. 14 (1), pp. 16430. Date of Electronic Publication: 2024 Jul 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Sepsis*/mortality , Sepsis*/blood , Sepsis*/complications , Blood Urea Nitrogen* , Tuberculosis*/mortality , Tuberculosis*/blood , Tuberculosis*/complications, Humans ; Male ; Female ; Middle Aged ; Aged ; Retrospective Studies ; Prognosis ; Serum Albumin/analysis ; Intensive Care Units ; Proportional Hazards Models |
مستخلص: | The relationship between blood urea nitrogen to albumin ratio (BAR) and the prognosis of patients with tuberculosis (TB) complicated by sepsis remains unclear. This study aimed to explore the association between BAR and overall patient prognosis. This was a retrospective cohort study of patients with TB complicated by sepsis who were admitted to the intensive care unit (ICU) of the Public Health Clinical Center of Chengdu between January 2019 and February 2023. The relationship between BAR values and prognosis in these patients was investigated using multivariate Cox regression, stratified analysis with interaction, restricted cubic spline (RCS), and threshold effect analysis. Sensitivity analyses were conducted to assess the robustness of the results. Our study included 537 TB patients complicated by sepsis admitted in the ICU, with a median age of 63.0 (48.0, 72.0) years; 76.7% of whom were men. The multivariate-restricted cubic spline analysis showed a non-linear association between BAR and patient prognosis. In the threshold analysis, we found that TB patients complicated by sepsis and a BAR < 7.916 mg/g had an adjusted hazard ratio (HR) for prognosis of 1.163 (95% CI 1.038-1.303; P = 0.009). However, when the BAR was ≥ 7.916 mg/g, there was no significant increase in the risk of death. The results of the sensitivity analysis were stable. (© 2024. The Author(s).) |
References: | Epidemiol Infect. 2021 Jan 05;149:e22. (PMID: 33397522) Immunity. 2021 Nov 9;54(11):2450-2464. (PMID: 34758337) Br J Anaesth. 2000 Oct;85(4):599-610. (PMID: 11064620) BMC Anesthesiol. 2022 Dec 28;22(1):404. (PMID: 36577937) Trop Med Infect Dis. 2022 Jul 27;7(8):. (PMID: 36006242) AJR Am J Roentgenol. 2013 Apr;200(4):827-9. (PMID: 23521456) Dtsch Arztebl Int. 2019 Oct 25;116(43):729-735. (PMID: 31755407) Am J Emerg Med. 2021 Aug;46:349-354. (PMID: 33069540) BMJ Open. 2018 Sep 12;8(9):e021979. (PMID: 30209156) Clin Transl Med. 2023 Jan;13(1):e1170. (PMID: 36629024) Nat Rev Nephrol. 2023 Jun;19(6):401-417. (PMID: 36823168) Int J Mol Sci. 2021 Apr 26;22(9):. (PMID: 33925831) Intensive Care Med. 2001 Mar;27(3):513-20. (PMID: 11355119) Pediatr Crit Care Med. 2020 Sep;21(9):e686-e695. (PMID: 32569242) Clin Infect Dis. 2022 May 30;74(10):1840-1849. (PMID: 34407175) JAMA. 2016 Feb 23;315(8):801-10. (PMID: 26903338) Monaldi Arch Chest Dis. 2021 Dec 03;92(3):. (PMID: 34865462) Sci Rep. 2023 Jun 20;13(1):10013. (PMID: 37340147) Medicine (Baltimore). 2023 Feb 17;102(7):e33007. (PMID: 36800572) Nat Med. 2018 Nov;24(11):1716-1720. (PMID: 30349085) Indian J Crit Care Med. 2021 May;25(Suppl 2):S150-S154. (PMID: 34345130) Respir Med Res. 2022 May;81:100886. (PMID: 35219226) Nat Rev Nephrol. 2018 Oct;14(10):607-625. (PMID: 30135570) Am J Trop Med Hyg. 2021 Jun 14;105(2):517-524. (PMID: 34125696) Nutrition. 1997 Sep;13(9 Suppl):45S-51S. (PMID: 9290109) JAMA Pediatr. 2019 Jun 1;173(6):515-516. (PMID: 31034035) Semin Immunopathol. 2017 Jul;39(5):517-528. (PMID: 28555385) Lancet. 2018 Jul 7;392(10141):75-87. (PMID: 29937192) J Clin Tuberc Other Mycobact Dis. 2021 Apr 20;23:100236. (PMID: 33997310) Am J Clin Nutr. 1997 Aug;66(2):464S-477S. (PMID: 9250134) Lancet. 2020 Jan 18;395(10219):200-211. (PMID: 31954465) J Inflamm Res. 2022 Feb 23;15:1227-1235. (PMID: 35558187) Geriatr Gerontol Int. 2013 Jan;13(1):107-15. (PMID: 22672187) BMC Anesthesiol. 2023 Jul 21;23(1):247. (PMID: 37479965) J Leukoc Biol. 2013 Mar;93(3):329-42. (PMID: 23136259) Ann Med. 2021 Dec;53(1):2192-2198. (PMID: 34783614) Eur J Clin Nutr. 2021 Sep;75(9):1309-1318. (PMID: 34163017) PLoS Med. 2007 Oct 16;4(10):e297. (PMID: 17941715) |
فهرسة مساهمة: | Keywords: Blood urea nitrogen to albumin ratio; ICU; Prognosis; Sepsis; TB |
المشرفين على المادة: | 0 (Serum Albumin) |
تواريخ الأحداث: | Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240801 |
رمز التحديث: | 20240801 |
مُعرف محوري في PubMed: | PMC11252304 |
DOI: | 10.1038/s41598-024-65622-z |
PMID: | 39013924 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
---|---|
DOI: | 10.1038/s41598-024-65622-z |