دورية أكاديمية
أعرض في EDS

The association between blood urea nitrogen to albumin ratio and the 28 day mortality in tuberculosis patients complicated by sepsis.

التفاصيل البيبلوغرافية
العنوان: The association between blood urea nitrogen to albumin ratio and the 28 day mortality in tuberculosis patients complicated by sepsis.
المؤلفون: Cui K; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China., Feng S; Ultrasonic Medicine, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Mao Y; Intensive Care Unit, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Luo H; Intensive Care Unit, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Yang J; Intensive Care Unit, Public Health Clinical Center of Chengdu, Chengdu, 610000, Sichuan, China., Xu R; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China., Bai L; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China. pangbailang@163.com.
المصدر: Scientific reports [Sci Rep] 2024 Jul 16; Vol. 14 (1), pp. 16430. Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Sepsis*/mortality , Sepsis*/blood , Sepsis*/complications , Blood Urea Nitrogen* , Tuberculosis*/mortality , Tuberculosis*/blood , Tuberculosis*/complications, Humans ; Male ; Female ; Middle Aged ; Aged ; Retrospective Studies ; Prognosis ; Serum Albumin/analysis ; Intensive Care Units ; Proportional Hazards Models
مستخلص: The relationship between blood urea nitrogen to albumin ratio (BAR) and the prognosis of patients with tuberculosis (TB) complicated by sepsis remains unclear. This study aimed to explore the association between BAR and overall patient prognosis. This was a retrospective cohort study of patients with TB complicated by sepsis who were admitted to the intensive care unit (ICU) of the Public Health Clinical Center of Chengdu between January 2019 and February 2023. The relationship between BAR values and prognosis in these patients was investigated using multivariate Cox regression, stratified analysis with interaction, restricted cubic spline (RCS), and threshold effect analysis. Sensitivity analyses were conducted to assess the robustness of the results. Our study included 537 TB patients complicated by sepsis admitted in the ICU, with a median age of 63.0 (48.0, 72.0) years; 76.7% of whom were men. The multivariate-restricted cubic spline analysis showed a non-linear association between BAR and patient prognosis. In the threshold analysis, we found that TB patients complicated by sepsis and a BAR < 7.916 mg/g had an adjusted hazard ratio (HR) for prognosis of 1.163 (95% CI 1.038-1.303; P = 0.009). However, when the BAR was ≥ 7.916 mg/g, there was no significant increase in the risk of death. The results of the sensitivity analysis were stable.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Blood urea nitrogen to albumin ratio; ICU; Prognosis; Sepsis; TB
المشرفين على المادة: 0 (Serum Albumin)
تواريخ الأحداث: Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240801
رمز التحديث: 20240801
مُعرف محوري في PubMed: PMC11252304
DOI: 10.1038/s41598-024-65622-z
PMID: 39013924
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-65622-z