دورية أكاديمية
أعرض في EDS

Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study.

التفاصيل البيبلوغرافية
العنوان: Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study.
المؤلفون: Chen Y; Department of Stomatology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No.N1, Shangcheng Avenue, Yiwu City, Zhejiang Province, 322000, China., Jin X; Department of Stomatology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No.N1, Shangcheng Avenue, Yiwu City, Zhejiang Province, 322000, China., Wang Q; Department of Stomatology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No.N1, Shangcheng Avenue, Yiwu City, Zhejiang Province, 322000, China., Hu S; Department of Stomatology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No.N1, Shangcheng Avenue, Yiwu City, Zhejiang Province, 322000, China., Huang X; Department of Stomatology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No.N1, Shangcheng Avenue, Yiwu City, Zhejiang Province, 322000, China. huangxv_cn@zju.edu.cn.
المصدر: BMC oral health [BMC Oral Health] 2024 Jul 16; Vol. 24 (1), pp. 806. Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Mendelian Randomization Analysis* , Chronic Periodontitis*/genetics , Chronic Periodontitis*/immunology , Phenotype*, Humans
مستخلص: Background: This study aims to explore the bidirectional causal relationship between immune cell phenotypes and chronic periodontitis using a Mendelian randomization framework.
Materials and Methods: Through a two-sample Mendelian randomization analysis, this research examined genetic data related to 731 immune cell traits and chronic periodontitis. Instrumental variables were chosen based on their genetic links to either immune traits or periodontitis. Various statistical techniques, including MR-Egger regression, weighted median, and inverse-variance weighted (IVW) analysis, were employed to determine the causal connections.
Results: Predominantly using the IVW method, 26 distinct immune phenotypes were identified as potentially influencing periodontitis (P < 0.05). Conversely, periodontitis potentially affected 33 different immune phenotypes (P < 0.05). The results for pleiotropy and sensitivity tests were stable. However, these associations lost significance after adjusting for the False Discovery Rate.
Conclusion: This study uncovers a complex bidirectional causal relationship between certain immune cell phenotypes and chronic periodontitis, underscoring the intricate interaction between the immune system and the pathogenesis of periodontal disease.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Causal inference; Chronic periodontitis; Immune cells; Immunity; Mendelian randomization
تواريخ الأحداث: Date Created: 20240716 Date Completed: 20240717 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11253491
DOI: 10.1186/s12903-024-04592-0
PMID: 39014403
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6831
DOI:10.1186/s12903-024-04592-0