دورية أكاديمية
أعرض في EDS

Exploring functional and structural connectivity disruptions in spinocerebellar ataxia type 3: Insights from gradient analysis.

التفاصيل البيبلوغرافية
العنوان: Exploring functional and structural connectivity disruptions in spinocerebellar ataxia type 3: Insights from gradient analysis.
المؤلفون: Wang X; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Chen H; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Wen R; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Ou P; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Huang Y; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Deng L; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Shi L; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Chen W; MR Research Collaboration Team, Siemens Healthineers Ltd., Wuhan, China., Chen H; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.; Biomedical Engineering, University of Electronic Science and Technology of China, Chengdu, China., Wang J; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., He C; College of Blockchain Industry, Chengdu University of Information Technology, Chengdu, China., Liu C; Department of Radiology, 7T Magnetic Resonance Translational Medicine Research Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
المصدر: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Jul; Vol. 30 (7), pp. e14842.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Wiley-Blackwell, c2008-
مواضيع طبية MeSH: Machado-Joseph Disease*/physiopathology , Machado-Joseph Disease*/diagnostic imaging , Machado-Joseph Disease*/complications , Machado-Joseph Disease*/pathology , Magnetic Resonance Imaging*/methods, Humans ; Female ; Male ; Middle Aged ; Adult ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain/pathology ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Prospective Studies ; Nerve Net/diagnostic imaging ; Nerve Net/physiopathology ; Nerve Net/pathology ; Diffusion Tensor Imaging/methods
مستخلص: Aims: Spinocerebellar Ataxia Type 3 (SCA3) is a rare genetic ataxia that impacts the entire brain and is characterized as a neurodegenerative disorder affecting the neural network. This study explores how alterations in the functional hierarchy, connectivity, and structural changes within specific brain regions significantly contribute to the heterogeneity of symptom manifestations in patients with SCA3.
Methods: We prospectively recruited 51 patients with SCA3 and 59 age-and sex-matched healthy controls. All participants underwent comprehensive multimodal neuroimaging and clinical assessments. In SCA3 patients, an innovative approach utilizing gradients in resting-state functional connectivity (FC) was employed to examine atypical patterns of hierarchical processing topology from sensorimotor to supramodal regions in the cerebellum and cerebrum. Coupling analyses of abnormal FC and structural connectivity among regions of interest (ROIs) in the brain were also performed to characterize connectivity alterations. Additionally, relationships between quantitative ROI values and clinical variables were explored.
Results: Patients with SCA3 exhibited either compression or expansion within the primary sensorimotor-to-supramodal gradient through four distinct calculation methods, along with disruptions in FC and structural connectivity coupling. A comprehensive correlation was identified between the altered gradients and the clinical manifestations observed in patients. Notably, altered fractional anisotropy values were not significantly correlated with clinical variables.
Conclusion: Abnormal gradients and connectivity in the cerebellar and cerebral cortices in SCA3 patients may contribute to disrupted motor-to-supramodal functions. Moreover, these findings support the potential utility of FCG analysis as a biomarker for diagnosing SCA3 and assessing treatment efficacy.
(© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
References: PLoS One. 2014 Nov 18;9(11):e112411. (PMID: 25405472)
Neurology. 2006 Jun 13;66(11):1717-20. (PMID: 16769946)
Neuroinformatics. 2016 Jul;14(3):339-51. (PMID: 27075850)
Neuroimage. 2002 May;16(1):241-50. (PMID: 11969331)
J Clin Exp Neuropsychol. 1998 Apr;20(2):194-200. (PMID: 9777473)
Nat Rev Dis Primers. 2019 Apr 11;5(1):24. (PMID: 30975995)
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19067-72. (PMID: 20956328)
Neuroimage. 2021 Apr 1;229:117706. (PMID: 33484851)
Handb Clin Neurol. 2018;154:181-202. (PMID: 29903439)
Hum Brain Mapp. 2023 Feb 15;44(3):927-936. (PMID: 36250694)
Elife. 2018 Aug 14;7:. (PMID: 30106371)
Trends Cogn Sci. 2018 Jan;22(1):21-31. (PMID: 29203085)
Neurosci Biobehav Rev. 2022 Apr;135:104574. (PMID: 35151769)
Mol Diagn Ther. 2016 Dec;20(6):617-622. (PMID: 27647319)
Front Neurosci. 2015 Nov 05;9:408. (PMID: 26594140)
J Neurol Sci. 1997 Feb 12;145(2):205-11. (PMID: 9094050)
J Neurophysiol. 2011 Sep;106(3):1125-65. (PMID: 21653723)
Mol Neurobiol. 2014 Dec;50(3):1111-23. (PMID: 24705817)
Nat Commun. 2019 Mar 4;10(1):1022. (PMID: 30833582)
Nat Commun. 2016 Jan 21;7:10340. (PMID: 26792267)
Assessment. 2012 Mar;19(1):21-30. (PMID: 22156721)
Int J Epidemiol. 2018 Oct 1;47(5):1518-1528. (PMID: 29868871)
Cereb Cortex. 2017 Feb 1;27(2):981-997. (PMID: 28184415)
Neuroimage. 2020 May 1;211:116624. (PMID: 32058002)
Gerontologist. 2019 Nov 16;59(6):e743-e763. (PMID: 30517634)
Front Aging Neurosci. 2022 Apr 11;14:773119. (PMID: 35478700)
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12574-12579. (PMID: 27791099)
Neuroimage. 2009 Jan 15;44(2):489-501. (PMID: 18835452)
Schizophr Bull. 1998;24(2):203-18. (PMID: 9613621)
Epidemiol Psychiatr Sci. 2019 Mar 14;29:e24. (PMID: 30867082)
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10240-5. (PMID: 17548818)
Biol Psychiatry. 2019 Nov 15;86(10):779-791. (PMID: 31515054)
Brain. 2014 Feb;137(Pt 2):598-609. (PMID: 24163276)
Hum Brain Mapp. 2015 Dec;36(12):5064-78. (PMID: 26359798)
Mov Disord. 2015 Sep;30(10):1391-9. (PMID: 26256273)
CNS Neurosci Ther. 2024 Jul;30(7):e14842. (PMID: 39014518)
Neuroimage Clin. 2022;36:103176. (PMID: 36063759)
Brain. 2015 May;138(Pt 5):1182-97. (PMID: 25818870)
معلومات مُعتمدة: 81601478 National Natural Science Foundation of China; 82071910 National Natural Science Foundation of China; 414Z395 Senior Medical Talents Program of Chongqing for Young and Middle-aged; Young and Middle-aged Senior Medical Talents Studio of Chongqing; 2024YQBJ-2 Excellent Young Talent Fund of the First Affiliated Hospital of the Army Medical University
فهرسة مساهمة: Keywords: coupling; functional connectivity; gradient; spinocerebellar ataxia type 3; structural connectivity
تواريخ الأحداث: Date Created: 20240716 Date Completed: 20240717 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11251871
DOI: 10.1111/cns.14842
PMID: 39014518
قاعدة البيانات: MEDLINE
الوصف
تدمد:1755-5949
DOI:10.1111/cns.14842