دورية أكاديمية
Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children.
| العنوان: | Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children. |
|---|---|
| المؤلفون: | Havens TN; Department of Pediatrics, University of Michigan Health, Ann Arbor, Michigan, USA., LeBeau P; Rho Federal Systems Division, Inc., Durham, North Carolina, USA.; Thermo Fisher Scientific, Wilmington, North Carolina, USA., Calatroni A; Rho Federal Systems Division, Inc., Durham, North Carolina, USA., Gern JE; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., O'Connor GT; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, USA., Wood RA; Department of Pediatrics, Johns Hopkins University Medical Center, Baltimore, Maryland, USA., Lamm C; Department of Pediatrics, Columbia University, New York, New York, USA., Krouse RZ; Rho Federal Systems Division, Inc., Durham, North Carolina, USA.; GSK, Philadelphia, Pennsylvania, USA., Visness CM; Thermo Fisher Scientific, Wilmington, North Carolina, USA., Gergen PJ; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Jackson DJ; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Bacharier LB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. |
| المصدر: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2024 Jul; Vol. 35 (7), pp. e14197. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Publishing Country of Publication: England NLM ID: 9106718 Publication Model: Print Cited Medium: Internet ISSN: 1399-3038 (Electronic) Linking ISSN: 09056157 NLM ISO Abbreviation: Pediatr Allergy Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010->: Oxford, UK : Blackwell Publishing Original Publication: Copenhagen : Munksgaard, c1990- |
| مواضيع طبية MeSH: | Respiratory Sounds* , Asthma*/epidemiology , Asthma*/virology , Phenotype* , Urban Population*, Humans ; Infant ; Female ; Male ; Child, Preschool ; Child ; Prospective Studies ; Rhinovirus ; Risk Factors ; Cohort Studies ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Picornaviridae Infections/epidemiology ; Picornaviridae Infections/complications ; Infant, Newborn |
| مستخلص: | Background: Viral wheezing is an important risk factor for asthma, which comprises several respiratory phenotypes. We sought to understand if the etiology of early-life wheezing illnesses relates to childhood respiratory and asthma phenotypes. Methods: Data were collected prospectively on 429 children in the Urban Environment and Childhood Asthma (URECA) birth cohort study through age 10 years. We identified wheezing illnesses and the corresponding viral etiology (PCR testing of nasal mucus) during the first 3 years of life. Six phenotypes of respiratory health were identified at 10 years of age based on trajectories of wheezing, allergic sensitization, and lung function. We compared the etiology of early wheezing illnesses to these wheezing respiratory phenotypes and the development of asthma. Results: In the first 3 years of life, at least one virus was detected in 324 (67%) of the 483 wheezing episodes documented in the study cohort. Using hierarchical partitioning we found that non-viral wheezing episodes accounted for the greatest variance in asthma diagnosed at both 7 and 10 years of age (8.0% and 5.8% respectively). Rhinovirus wheezing illnesses explained the most variance in respiratory phenotype outcome followed by non-viral wheezing episodes (4.9% and 3.9% respectively) at 10 years of age. Conclusion and Relevance: Within this high-risk urban-residing cohort in early life, non-viral wheezing episodes were frequently identified and associated with asthma development. Though rhinovirus wheezing illnesses had the greatest association with phenotype outcome, the specific etiology of wheezing episodes in early life provided limited information about subsequent wheezing phenotypes. (© 2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.) |
| References: | Zahran HS, Bailey CM, Damon SA, Garbe PL, Breysse PN. Vital signs: asthma in children – United States, 2001–2016. MMWR Morb Mortal Wkly Rep. 2018;67(5):149‐155. doi:10.15585/mmwr.mm6705e1. Johnson CC, Havstad SL, Ownby DR, et al. Pediatric asthma incidence rates in the United States from 1980 to 2017. J Allergy Clin Immunol. 2021;148(5):1270‐1280. doi:10.1016/j.jaci.2021.04.027. Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high‐risk children. Am J Respir Crit Care Med. 2008;178(7):667‐672. doi:10.1164/rccm.200802-309OC. Lemanske RF Jr, Jackson DJ, Gangnon RE, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol. 2005;116(3):571‐577. doi:10.1016/j.jaci.2005.06.024. Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354(9178):541‐545. doi:10.1016/S0140-6736(98)10321-5. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med. 2000;161(5):1501‐1507. doi:10.1164/ajrccm.161.5.9906076. Lukkarinen M, Koistinen A, Turunen R, Lehtinen P, Vuorinen T, Jartti T. Rhinovirus‐induced first wheezing episode predicts atopic but not nonatopic asthma at school age. J Allergy Clin Immunol. 2017;140(4):988‐995. doi:10.1016/j.jaci.2016.12.991. Rubner FJ, Jackson DJ, Evans MD, et al. Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence. J Allergy Clin Immunol. 2017;139(2):501‐507. doi:10.1016/j.jaci.2016.03.049. Jackson DJ, Evans MD, Gangnon RE, et al. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med. 2012;185(3):281‐285. doi:10.1164/rccm.201104-0660OC. Gern JE, Pappas T, Visness CM, et al. Comparison of the etiology of viral respiratory illnesses in inner‐city and suburban infants. J Infect Dis. 2012;206(9):1342‐1349. doi:10.1093/infdis/jis504. Altman MC, Gill MA, Whalen E, et al. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019;20(5):637‐651. doi:10.1038/s41590-019-0347-8. Robinson PFM, Pattaroni C, Cook J, et al. Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze. J Allergy Clin Immunol. 2019;143(4):1607‐1610.e3. doi:10.1016/j.jaci.2018.12.985. Schwerk N, Brinkmann F, Soudah B, Kabesch M, Hansen G. Wheeze in preschool age is associated with pulmonary bacterial infection and resolves after antibiotic therapy. PLoS One. 2011;6(11):e27913. Nishimura KK, Galanter JM, Roth LA, et al. Early‐life air pollution and asthma risk in minority children. The GALA II and SAGE II studies. Am J Respir Crit Care Med. 2013;188(3):309‐318. doi:10.1164/rccm.201302-0264OC. Bacharier LB, Beigelman A, Calatroni A, et al. Longitudinal phenotypes of respiratory health in a high‐risk urban birth cohort. Am J Respir Crit Care Med. 2019;199(1):71‐82. doi:10.1164/rccm.201801-0190OC. Gern JE, Visness CM, Gergen PJ, et al. The urban environment and childhood asthma (URECA) birth cohort study: design, methods, and study population. BMC Pulm Med. 2009;9:17. doi:10.1186/1471-2466-9-17. Lynch SV, Wood RA, Boushey H, et al. Effects of early‐life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol. 2014;134(3):593‐601.e12. doi:10.1016/j.jaci.2014.04.018. Gern JE, Martin MS, Anklam KA, et al. Relationships among specific viral pathogens, virus‐induced interleukin‐8, and respiratory symptoms in infancy. Pediatr Allergy Immunol. 2002;13(6):386‐393. doi:10.1034/j.1399-3038.2002.01093.x. Lee W‐M, Grindle K, Pappas T, et al. High‐throughput, sensitive, and accurate multiplex PCR‐microsphere flow cytometry system for large‐scale comprehensive detection of respiratory viruses. J Clin Microbiol. 2007;45(8):2626‐2634. doi:10.1128/JCM.02501-06. O'Connor GT, Lynch SV, Bloomberg GR, et al. Early‐life home environment and risk of asthma among inner‐city children. J Allergy Clin Immunol. 2018;141(4):1468‐1475. doi:10.1016/j.jaci.2017.06.040. Altman MC, Calatroni A, Ramratnam S, et al. Endotype of allergic asthma with airway obstruction in urban children. J Allergy Clin Immunol. 2021;148(5):1198‐1209. doi:10.1016/j.jaci.2021.02.040. Chevan A, Sutherland M. Hierarchical partitioning. Am Stat. 1991;45(2):90‐96. doi:10.1080/00031305.1991.10475776. Altman MC, Kattan M, O'Connor GT, et al. Associations between outdoor air pollutants and non‐viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis. Lancet Planet Health. 2023;7(1):e33‐e44. doi:10.1016/s2542-5196(22)00302-3. Altman MC, Beigelman A, Ciaccio C, et al. Evolving concepts in how viruses impact asthma: a work group report of the microbes in allergy Committee of the American Academy of allergy, Asthma & Immunology. J Allergy Clin Immunol. 2020;145(5):1332‐1344. doi:10.1016/j.jaci.2019.12.904. Lewis TC, Metitiri EE, Mentz GB, et al. Impact of community respiratory viral infections in urban children with asthma. Ann Allergy Asthma Immunol. 2019;122(2):175‐183.e2. doi:10.1016/j.anai.2018.10.021. Simpson A, Custovic A, Pipis S, Adisesh A, Faragher B, Woodcock A. Exhaled nitric oxide, sensitization, and exposure to allergens in patients with asthma who are not taking inhaled steroids. Am J Respir Crit Care Med. 1999;160(1):45‐49. doi:10.1164/ajrccm.160.1.9809091. Steerenberg PA, Nierkens S, Fischer PH, et al. Traffic‐related air pollution affects peak expiratory flow, exhaled nitric oxide, and inflammatory nasal markers. Arch Environ Health. 2001;56(2):167‐174. doi:10.1080/00039890109604069. Bisgaard H, Hermansen MN, Bønnelykke K, et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ. 2010;341:c4978. doi:10.1136/bmj.c4978. Kloepfer KM, Lee WM, Pappas TE, et al. Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations. J Allergy Clin Immunol. 2014;133(5):1301‐1307.e1–3. doi:10.1016/j.jaci.2014.02.030. Olenec JP, Kim WK, Lee W‐M, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol. 2010;125(5):1001‐1006.e1. doi:10.1016/j.jaci.2010.01.059. Salo PM, Arbes SJ Jr, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005–2006. J Allergy Clin Immunol. 2014;134(2):350‐359. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson children's respiratory study: 1980 to present. J Allergy Clin Immunol. 2003;111(4):661‐675. doi:10.1067/mai.2003.162. van der Zalm MM, Uiterwaal CS, Wilbrink B, Koopman M, Verheij TJ, van der Ent CK. The influence of neonatal lung function on rhinovirus‐associated wheeze. Am J Respir Crit Care Med. 2011;183(2):262‐267. doi:10.1164/rccm.200905-0716OC. Johnson CC, Chandran A, Havstad S, et al. US childhood asthma incidence rate patterns from the ECHO consortium to identify high‐risk groups for primary prevention. JAMA Pediatr. 2021;175(9):919‐927. doi:10.1001/jamapediatrics.2021.0667. Ramratnam SK, Lockhart A, Visness CM, et al. Maternal stress and depression are associated with respiratory phenotypes in urban children. J Allergy Clin Immunol. 2021;148(1):120‐127. doi:10.1016/j.jaci.2021.03.005. Ramratnam SK, Visness CM, Jaffee KF, et al. Relationships among maternal stress and depression, type 2 responses, and recurrent wheezing at age 3 years in low‐income urban families. Am J Respir Crit Care Med. 2017;195(5):674‐681. doi:10.1164/rccm.201602-0272OC. Nyenhuis SM, Krishnan JA, Berry A, et al. Race is associated with differences in airway inflammation in patients with asthma. J Allergy Clin Immunol. 2017;140(1):257‐265.e11. doi:10.1016/j.jaci.2016.10.024. Zanobetti A, Ryan PH, Coull B, et al. Childhood asthma incidence, early and persistent wheeze, and neighborhood socioeconomic factors in the ECHO/CREW consortium. JAMA Pediatr. 2022;176(8):759‐767. |
| فهرسة مساهمة: | Keywords: asthma; children; phenotypes; viral; wheeze |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| DOI: | 10.1111/pai.14197 |
| PMID: | 39016335 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-3038 |
|---|---|
| DOI: | 10.1111/pai.14197 |