دورية أكاديمية
Distal but not local auditory information supports spatial representations by place cells.
| العنوان: | Distal but not local auditory information supports spatial representations by place cells. |
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| المؤلفون: | Dolón Vera L; Ruhr University Bochum, Medical Faculty, Department of Neurophysiology, Universitätsstrasse 150, MA4/150, Bochum 44780, Germany.; Ruhr University Bochum, International Graduate School of Neuroscience, Universitätsstrasse 150, FNO 01, Bochum 44780, Germany., Dietz B; Ruhr University Bochum, Medical Faculty, Department of Neurophysiology, Universitätsstrasse 150, MA4/150, Bochum 44780, Germany.; Ruhr University Bochum, International Graduate School of Neuroscience, Universitätsstrasse 150, FNO 01, Bochum 44780, Germany., Manahan-Vaughan D; Ruhr University Bochum, Medical Faculty, Department of Neurophysiology, Universitätsstrasse 150, MA4/150, Bochum 44780, Germany. |
| المصدر: | Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Jul 03; Vol. 34 (7). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Oxford University Press, c1991- |
| مواضيع طبية MeSH: | Cues* , Acoustic Stimulation* , Place Cells*/physiology , Space Perception*/physiology , Rats, Long-Evans*, Animals ; Male ; CA1 Region, Hippocampal/physiology ; CA1 Region, Hippocampal/cytology ; Rats ; Auditory Perception/physiology ; Action Potentials/physiology ; Spatial Navigation/physiology |
| مستخلص: | Sound is an important navigational cue for mammals. During spatial navigation, hippocampal place cells encode spatial representations of the environment based on visual information, but to what extent audiospatial information can enable reliable place cell mapping is largely unknown. We assessed this by recording from CA1 place cells in the dark, under circumstances where reliable visual, tactile, or olfactory information was unavailable. Male rats were exposed to auditory cues of different frequencies that were delivered from local or distal spatial locations. We observed that distal, but not local cue presentation, enables and supports stable place fields, regardless of the sound frequency used. Our data suggest that a context dependency exists regarding the relevance of auditory information for place field mapping: whereas locally available auditory cues do not serve as a salient spatial basis for the anchoring of place fields, auditory cue localization supports spatial representations by place cells when available in the form of distal information. Furthermore, our results demonstrate that CA1 neurons can effectively use auditory stimuli to generate place fields, and that hippocampal pyramidal neurons are not solely dependent on visual cues for the generation of place field representations based on allocentric reference frames. (© The Author(s) 2024. Published by Oxford University Press.) |
| معلومات مُعتمدة: | 122679504 German Research Foundation |
| فهرسة مساهمة: | Keywords: auditory; electrophysiology; place cell; sensory; spatial navigation |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| DOI: | 10.1093/cercor/bhae202 |
| PMID: | 39016432 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-2199 |
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| DOI: | 10.1093/cercor/bhae202 |