دورية أكاديمية
Biocompatible Hybrid Graphenic Thin Coatings on Flexible Substrates through Matrix-Assisted Pulsed Laser Evaporation (MAPLE).
| العنوان: | Biocompatible Hybrid Graphenic Thin Coatings on Flexible Substrates through Matrix-Assisted Pulsed Laser Evaporation (MAPLE). |
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| المؤلفون: | Alfe M; Institute of Sciences and Technologies for Sustainable Energy and Mobility (CNR-STEMS), Via G. Marconi, 4, Naples 80125, Italy., Minopoli G; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini, 5, Naples 80131, Italy., Tartaglia M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini, 5, Naples 80131, Italy., Gargiulo V; Institute of Sciences and Technologies for Sustainable Energy and Mobility (CNR-STEMS), Via G. Marconi, 4, Naples 80125, Italy., Ausanio G; Department of Physics 'E. Pancini', University of Naples Federico II and Institute for Superconductors Innovative Materials and Devices (CNR-SPIN), via Cinthia 26, Naples 80126, Italy. |
| المصدر: | ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 31; Vol. 16 (30), pp. 38956-38967. Date of Electronic Publication: 2024 Jul 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Indoles*/chemistry , Graphite*/chemistry , Polymers*/chemistry , Coated Materials, Biocompatible*/chemistry , Coated Materials, Biocompatible*/pharmacology, Mice ; Animals ; Humans ; NIH 3T3 Cells ; Lasers ; HeLa Cells ; HaCaT Cells |
| مستخلص: | This work reports the production of biocompatible thin layers for biomedical applications based on a graphene-like material (GL), a graphene-related material (GRM) obtained from carbon black. GL was combined in a hybrid fashion with polydopamine (pDA), a mussel-inspired water-resistant wet adhesive bonding obtained by the oxidative polymerization of dopamine (DA), and polyvinyl pyrrolidinone (PVP), a nontoxic synthetic polymer with intrinsic adhesion properties, to obtain a tighter adhesion of the thin layer to the substrate (silicone slices). Matrix-assisted pulsed laser evaporation (MAPLE) was used to coat PDMS slices with thin films of GL-pDA and GL-PVP directly from their frozen suspensions in water. The results indicate that the relevant chemical-physical characteristics of both thin films (evidenced by FTIR and AFM) were maintained after MAPLE deposition and that the films exhibit uniformity also at the nanometric level. After deposition, the GL-pDA and GL-PVP films underwent a biological survey toward murine fibroblasts (NIH3T3), human keratinocytes (HaCAT), and human cervical adenocarcinoma epithelial-like (HeLa) cells to assess the feasibility of this approach. Results indicate that both the GL-pDA and GL-PVP films did not perturb the biological parameters evaluated, including cytoskeleton alterations. Both hybrid films enhanced the effects of GL on cellular vitality across all cell lines. Specifically, the GL-pDA film exhibited a more stable effect over time (up to 72 h), whereas the GL-PVP film behaved similarly to the GL film in NIH3T3 and HeLa cell lines after long-term exposure. These promising results make the GL-pDA and GL-PVP films potential candidates for the manufacture of coated flexible devices for biomedical applications. |
| فهرسة مساهمة: | Keywords: MAPLE; biocompatibility; graphene-related materials; hybrids; laser deposition; polydopamine; thin films |
| المشرفين على المادة: | 0 (polydopamine) 0 (Indoles) 7782-42-5 (Graphite) 0 (Polymers) 0 (Coated Materials, Biocompatible) |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240801 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1021/acsami.4c06000 |
| PMID: | 39018469 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1944-8252 |
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| DOI: | 10.1021/acsami.4c06000 |