دورية أكاديمية
Evaluation of immunophenotype and inflammation in canine mammary neoplasms with solid arrangement.
| العنوان: | Evaluation of immunophenotype and inflammation in canine mammary neoplasms with solid arrangement. |
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| المؤلفون: | Flecher MC; Department of General Pathology/Laboratory of Comparative Pathology, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270-091, Brazil; Department of Veterinary Pathology, Universidade Vila Velha, Vila Velha, Espirito Santo, 29101-420, Brazil., Balabram D; Department of Surgery, School of Medicine, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270-091, Brazil., Salles YA; Department of Veterinary Pathology, Universidade Vila Velha, Vila Velha, Espirito Santo, 29101-420, Brazil., Souza FR; Department of General Pathology/Laboratory of Comparative Pathology, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270-091, Brazil., Estrela-Lima A; Department of Anatomy, Pathology and Veterinary Clinics, Federal University of Bahia, Salvador, Bahia, 401170-110, Brazil., Nakagaki KYR; Department of General Pathology/Laboratory of Comparative Pathology, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270-091, Brazil., Cassali GD; Department of General Pathology/Laboratory of Comparative Pathology, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270-091, Brazil. Electronic address: geovanni.cassali@gmail.com. |
| المصدر: | Journal of comparative pathology [J Comp Pathol] 2024 Aug; Vol. 213, pp. 1-9. Date of Electronic Publication: 2024 Jul 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0102444 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3129 (Electronic) Linking ISSN: 00219975 NLM ISO Abbreviation: J Comp Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Elsevier Original Publication: Liverpool, University Press. |
| مواضيع طبية MeSH: | Mammary Neoplasms, Animal*/pathology , Dog Diseases*/pathology , Dog Diseases*/immunology , Immunophenotyping* , Inflammation*, Animals ; Dogs ; Female ; Biomarkers, Tumor/analysis |
| مستخلص: | Morphological and immunohistochemical studies of solid arrangement canine mammary carcinomas have shown that the different histological types may be characterized by proliferation of epithelial and/or myoepithelial cells. However, little is known about immunophenotypes and the importance of inflammation as prognostic factors in these neoplasms. The objective of the present study was to characterize the immunophenotype and degree of inflammation in the solid type of canine mammary neoplasm and to investigate their association with metastasis, Ki-67 index, tumour size, necrosis and survival. Sixty-five carcinomas with solid pattern, basaloid carcinomas, solid papillary carcinomas, malignant adenomyoepitheliomas (MAMEs) or malignant myoepitheliomas (MMEs) were investigated. Luminal A, luminal B HER2 negative and HER2 positive, HER2 overexpressed and triple negative immunophenotypes were immunolabelled as were Ki-67 protein and cyclooxygenase-2 (Cox-2). Histological peritumoural and intratumoural inflammatory infiltrates were graded (distribution × intensity) and the presence of necrosis identified. We found a statistical difference between histological types and immunophenotypes, with MME and MAME having a higher occurrence of luminal A, whereas most neoplasms had the luminal B HER-negative immunophenotype. There was no correlation between immunophenotype and degree of peri- and intratumoural inflammation, nodal metastasis, necrosis or tumour size. An increased degree of peri- and intratumoural inflammation was significantly associated with lymph node metastasis, and more severe intratumoural inflammation was associated with the presence of tumour necrosis. Tumour size, Ki-67 index and Cox-2 score were not associated with inflammation in either peri- or intratumoural regions. No difference was observed in survival in relation to immunophenotype or degree of inflammation, but the Cox regression model revealed that nodal metastasis influenced the risk of death. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Ki-67; bitch; immunohistochemistry; mammary cancer; survival; tumour-infiltrating lymphocytes |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240826 Latest Revision: 20240826 |
| رمز التحديث: | 20240827 |
| DOI: | 10.1016/j.jcpa.2024.06.004 |
| PMID: | 39018987 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-3129 |
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| DOI: | 10.1016/j.jcpa.2024.06.004 |