التفاصيل البيبلوغرافية
| العنوان: |
Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr. |
| المؤلفون: |
Minh Nguyen H; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Nguyen KP; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Le ATP; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Nguyen NHT; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Vu-Huynh LK; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Le CKT; Department of Facility Management, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Delpe Acharige A; Baylor Synthesis and Drug-Lead Discovery Lab, Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA., Hull K; Baylor Synthesis and Drug-Lead Discovery Lab, Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA., Romo D; Baylor Synthesis and Drug-Lead Discovery Lab, Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA. |
| المصدر: |
Natural product research [Nat Prod Res] 2024 Jul 17, pp. 1-11. Date of Electronic Publication: 2024 Jul 17. |
| Publication Model: |
Ahead of Print |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مستخلص: |
This study explored, for the first time, the antioxidant (total antioxidant content, reducing power, ferric ion reducing antioxidant power, hydroxyl radical scavenging, ferrous ion-chelating assays), anti-tyrosinase, anti-inflammatory properties, and hepatoprotective effect in HepG2 cell lines of Ochna integerrima (Loureiro) Merrill flowers and seeds. All extracts except n -hexane exhibited significant antioxidant activity, with high levels of tannin and proanthocyanidins. Luteolin ( 1 ), 6- γ , γ -dimethylallylkaempferol7- O - β -d-glucopyranoside ( 2 ), 6- γ , γ -dimethylallylquercetin7- O - β -d-glucopyranoside ( 3 ), and 6- γ , γ -dimethylallyldihydrokaempferol 7- O - β -d-glucopyranoside ( 4 ) were isolated using semi-preparative HPLC. Compounds 1 - 3 demonstrated good anti-tyrosinase activity. The most active hepatoprotective extracts were found to be aqueous extracts. The flower extracts exhibited greater anti-inflammatory properties by the decrease of NO in RAW 264.7 cells and bovine serum albumin protein. Among them, the n -hexane and EtOAc extracts from flowers displayed promising anti-inflammatory activity. This was predicted by in silico analysis of 1 - 4 . In summary, O. integerrima appears to be a promising natural source for antioxidant, anti-tyrosinase, and anti-inflammatory applications. |
| فهرسة مساهمة: |
Keywords: Anti-inflammatory; Ochna integerrima (Lour.) Merr.; anti-tyrosinase; antioxidant; hepatoprotective effect |
| تواريخ الأحداث: |
Date Created: 20240718 Latest Revision: 20240718 |
| رمز التحديث: |
20240718 |
| DOI: |
10.1080/14786419.2024.2378195 |
| PMID: |
39021067 |
| قاعدة البيانات: |
MEDLINE |
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