دورية أكاديمية
أعرض في EDS

A study protocol for risk stratification in children with concussion (RSiCC): Theoretical framework, design, and methods.

التفاصيل البيبلوغرافية
العنوان: A study protocol for risk stratification in children with concussion (RSiCC): Theoretical framework, design, and methods.
المؤلفون: Reuter-Rice K; Duke University School of Nursing, Durham, North Carolina, United States of America.; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States of America.; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, United States of America., Fitterer AN; Duke University School of Nursing, Durham, North Carolina, United States of America., Duquette P; Department of Physical Medicine & Rehabilitation, Univeristy of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America., Yang Q; Duke University School of Nursing, Durham, North Carolina, United States of America., Palipana AK; Duke University School of Nursing, Durham, North Carolina, United States of America., Laskowitz D; Department of Neurology, Duke University School of Medicine, Durham, North Carolina, United States of America., Garrett ME; Duke University School of Medicine, Duke Molecular Physiology Institute, Durham, North Carolina, United States of America., Fletcher M; Duke University School of Nursing, Durham, North Carolina, United States of America., Smith J; Duke University School of Medicine, Duke Molecular Physiology Institute, Durham, North Carolina, United States of America., Makor L; Department of Public Instruction, State of North Carolina, Office of Exceptional Children, Raleigh, North Carolina, United States of America., Grant G; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, United States of America., Ramsey K; Duke University Health System, Carolina Family Practice and Sports Medicine, Carolina Sports Concussion Clinic, Cary, North Carolina, United States of America., Bloom OJ; Duke University Health System, Carolina Family Practice and Sports Medicine, Carolina Sports Concussion Clinic, Cary, North Carolina, United States of America., Ashley-Koch AE; Duke University School of Medicine, Duke Molecular Physiology Institute, Durham, North Carolina, United States of America.
المصدر: PloS one [PLoS One] 2024 Jul 18; Vol. 19 (7), pp. e0306399. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Brain Concussion* , Post-Concussion Syndrome*/diagnosis, Humans ; Child ; Adolescent ; Male ; Female ; Biomarkers ; Risk Assessment
مستخلص: Research shows that one in five children will experience a concussion by age 16. Compared to adults, children experience longer and more severe postconcussive symptoms (PCS), with severity and duration varying considerably among children and complicating management of these patients. Persistent PCS can result in increased school absenteeism, social isolation, and psychological distress. Although early PCS diagnosis and access to evidence-based interventions are strongly linked to positive health and academic outcomes, symptom severity and duration are not fully explained by acute post-injury symptoms. Prior research has focused on the role of neuroinflammation in mediating PCS and associated fatigue; however relationship between inflammatory biomarkers and PCS severity, has not examined longitudinally. To identify which children are at high risk for persistent PCS and poor health, academic, and social outcomes, research tracking PCS trajectories and describing school-based impacts across the entire first year postinjury is critically needed. This study will 1) define novel PCS trajectory typologies in a racially/ethnically diverse population of 500 children with concussion (11-17 years, near equal distribution by sex), 2) identify associations between these typologies and patterns of inflammatory biomarkers and genetic variants, 3) develop a risk stratification model to identify children at risk for persistent PCS; and 4) gain unique insights and describe PCS impact, including fatigue, on longer-term academic and social outcomes. We will be the first to use NIH's symptom science model and patient-reported outcomes to explore the patterns of fatigue and other physical, cognitive, psychological, emotional and academic responses to concussion in children over a full year. Our model will enable clinicians and educators to identify children most at risk for poor long-term health, social, and academic outcomes after concussion. This work is critical to meeting our long-term goal of developing personalized concussion symptom-management strategies to improve outcomes and reduce disparities in the health and quality of life of children.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Reuter-Rice et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
References: Neurorehabil Neural Repair. 2012 Jan;26(1):36-47. (PMID: 21788436)
Br J Sports Med. 2017 Jun;51(12):935-940. (PMID: 28455363)
J Neurol. 2006 Aug;253(8):1041-7. (PMID: 16708266)
Clin Psychol Rev. 2018 Jul;63:41-55. (PMID: 29902711)
Psychoneuroendocrinology. 2004 Feb;29(2):125-40. (PMID: 14604596)
Annu Rev Nurs Res. 2015;33:185-217. (PMID: 25946386)
Med Care. 2007 May;45(5 Suppl 1):S3-S11. (PMID: 17443116)
Sci Rep. 2018 Feb 14;8(1):3031. (PMID: 29445205)
PM R. 2010 Dec;2(12 Suppl 2):S241-52. (PMID: 21172686)
Ann Neurol. 1990 Mar;27(3):327. (PMID: 2327740)
Br J Anaesth. 2007 Jul;99(1):43-8. (PMID: 17556350)
World J Diabetes. 2014 Dec 15;5(6):730-8. (PMID: 25512775)
J Child Neurol. 2016 Jan;31(1):57-67. (PMID: 25330797)
Appl Neuropsychol. 2006;13(3):166-74. (PMID: 17361669)
Pediatrics. 2009 Mar;123(3):735-43. (PMID: 19254996)
J Int Neuropsychol Soc. 2011 Sep;17(5):886-95. (PMID: 21813031)
Neurosurgery. 2016 Dec;79(6):912-929. (PMID: 27741219)
BMJ. 2005 Apr 30;330(7498):1012-5. (PMID: 15860829)
Neuropsychol Rehabil. 2017 Oct;27(7):1047-1055. (PMID: 28278589)
AMIA Annu Symp Proc. 2017 Feb 10;2016:1737-1746. (PMID: 28269932)
Neurosci Biobehav Rev. 2014 Nov;47:684-716. (PMID: 25451201)
Psychol Med. 1996 Mar;26(2):245-56. (PMID: 8685281)
Neuroscientist. 2015 Aug;21(4):424-41. (PMID: 25059577)
Qual Life Res. 2013 Nov;22(9):2417-27. (PMID: 23378106)
Neuropsychol Rev. 1997 Jun;7(2):77-85. (PMID: 9253770)
PM R. 2009 May;1(5):406-20. (PMID: 19627927)
Brain Behav Immun. 2017 May;62:230-244. (PMID: 28089639)
Disabil Rehabil. 2017 Mar;39(6):544-550. (PMID: 26971917)
Ther Drug Monit. 1994 Oct;16(5):437-43. (PMID: 7846740)
J Head Trauma Rehabil. 2006 Sep-Oct;21(5):375-8. (PMID: 16983222)
Nurs Outlook. 2015 Jul-Aug;63(4):484-7. (PMID: 26187087)
Brain Inj. 2010;24(13-14):1528-38. (PMID: 21058899)
Concussion. 2017 Oct 27;2(4):CNC50. (PMID: 30202591)
J Neurotrauma. 2013 Oct 15;30(20):1710-6. (PMID: 23768161)
J Sci Med Sport. 2021 Dec;24(12):1235-1239. (PMID: 34244083)
Praxis (Bern 1994). 2016 May 11;105(10):569-75. (PMID: 27167479)
Brain Imaging Behav. 2014 Sep;8(3):420-34. (PMID: 22878895)
J Rehabil Med. 2004 Feb;(43 Suppl):28-60. (PMID: 15083870)
JAMA Pediatr. 2018 Nov 1;172(11):e182853. (PMID: 30193284)
Clin J Sport Med. 2018 Mar;28(2):125-129. (PMID: 28708709)
J Neurotrauma. 2012 Mar 01;29(4):672-7. (PMID: 22106839)
Brain Inj. 2009 Mar;23(3):213-9. (PMID: 19205957)
J Clin Med. 2020 Aug 20;9(9):. (PMID: 32825238)
Stat Methods Med Res. 2018 Jul;27(7):2015-2023. (PMID: 29846144)
Am J Public Health. 2012 Nov;102(11):2074-9. (PMID: 22994196)
Clin Chem. 1983 Oct;29(10):1752-6. (PMID: 6225566)
Front Immunol. 2019 Aug 06;10:1827. (PMID: 31447842)
Pediatrics. 2018 Nov;142(5):. (PMID: 30323108)
Ann N Y Acad Sci. 2015 May;1345:89-98. (PMID: 25809391)
J Clin Epidemiol. 1996 Dec;49(12):1373-9. (PMID: 8970487)
J Sports Med Phys Fitness. 2017 Jan-Feb;57(1-2):77-89. (PMID: 25242101)
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240718 Date Completed: 20240718 Latest Revision: 20240720
رمز التحديث: 20240720
مُعرف محوري في PubMed: PMC11257289
DOI: 10.1371/journal.pone.0306399
PMID: 39024215
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0306399