دورية أكاديمية
Initial MRI findings predictive of a pathological complete response to neoadjuvant treatments in HER2-positive breast cancers.
| العنوان: | Initial MRI findings predictive of a pathological complete response to neoadjuvant treatments in HER2-positive breast cancers. |
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| المؤلفون: | Ribrag A; Department of Radiology, Institut Curie, Paris, France. Electronic address: anne.ribrag@curie.fr., Lissavalid E; Department of Radiology, Institut Curie, Paris, France., Fayard J; Department of Radiology, Institut Curie, Saint-Cloud, France., Djerroudi L; Department of Pathology, Institut Curie, Paris, France., Ghislain MS; Department of Medical Oncology, Institut Curie, Paris, France., Ramtohul T; Department of Radiology, Institut Curie, Paris, France., Tardivon A; Department of Radiology, Institut Curie, Paris, France. |
| المصدر: | European journal of radiology [Eur J Radiol] 2024 Sep; Vol. 178, pp. 111625. Date of Electronic Publication: 2024 Jul 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Ltd Original Publication: Stuttgart ; New York : Thieme, [c1981- |
| مواضيع طبية MeSH: | Breast Neoplasms*/diagnostic imaging , Breast Neoplasms*/therapy , Neoadjuvant Therapy*/methods , Receptor, ErbB-2*/metabolism , Pathologic Complete Response*, Adult ; Aged ; Female ; Humans ; Middle Aged ; Magnetic Resonance Imaging ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Purpose: This study aimed to determine if initial MRI findings could predict a pathological complete response (pCR) following neoadjuvant systemic therapy (NST) in HER2-positive breast cancers. Methods: The study retrospectively included 111 patients (Center 1, training set) and 71 patients (Center 2, validation set) with HER2-positive cancer who underwent NST. Initial clinicopathological data and MRI findings were recorded. Continuous variables were analyzed using the Mann-Whitney and Student's t-tests, while categorical variables were analyzed using the χ 2 or Fisher's exact test. Univariate analysis was conducted to determine the associations between these variables and pathological complete response (pCR), defined as the absence of invasive malignant cells in the breast and lymph nodes. Interobserver reproducibility was assessed for associated non-mass enhancement (NME) parameter by analyzing 50 MR studies (intraclass correlation coefficient). Results: pCR was achieved in 67 patients, 51 (46 %) from Center 1 and 16 (23%) from Center 2 (p = 0.003), with significant differences between Centers 1 and 2 in tumor-infiltrating lymphocyte levels and lymphovascular invasion (p < 0.001). The initial presence of suspicious associated NME was the only significant parameter predictive of pCR (p < 0.001 for Center 1 and 0.04 for Center 2). The inter-observer reproducibility for this MRI feature was good, with an intraclass correlation coefficient of 0.872 (95 % CI: 0.73-1.00). Conclusion: The presence of suspicious associated NME in HER2-positive cancers on the initial MRI study was predictive of achieving pCR after NST. This significant preliminary finding warrants confirmation through prospective multicenter studies. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; Her2 gene; Magnetic resonance imaging; Pathologic complete response |
| المشرفين على المادة: | EC 2.7.10.1 (ERBB2 protein, human) EC 2.7.10.1 (Receptor, ErbB-2) |
| تواريخ الأحداث: | Date Created: 20240718 Date Completed: 20240816 Latest Revision: 20240819 |
| رمز التحديث: | 20240819 |
| DOI: | 10.1016/j.ejrad.2024.111625 |
| PMID: | 39024664 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7727 |
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| DOI: | 10.1016/j.ejrad.2024.111625 |