دورية أكاديمية
أعرض في EDS

GLP-1R agonist therapy and vaccine response: Neglected implications.

التفاصيل البيبلوغرافية
العنوان: GLP-1R agonist therapy and vaccine response: Neglected implications.
المؤلفون: van Niekerk G; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Division of Virology, Antiviral Drug and Vaccine Research, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium., Coelmont L; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Division of Virology, Antiviral Drug and Vaccine Research, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium., Alpizar YA; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Division of Virology, Antiviral Drug and Vaccine Research, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium., Kelchtermans L; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Division of Virology, Antiviral Drug and Vaccine Research, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium., Broeckhoven E; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Division of Virology, Antiviral Drug and Vaccine Research, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium., Dallmeier K; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Division of Virology, Antiviral Drug and Vaccine Research, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium. Electronic address: kai.dallmeier@kuleuven.be.
المصدر: Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2024 Aug; Vol. 78, pp. 14-24. Date of Electronic Publication: 2024 Jul 15.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9612306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0305 (Electronic) Linking ISSN: 13596101 NLM ISO Abbreviation: Cytokine Growth Factor Rev Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Elsevier Science, c1996-
مواضيع طبية MeSH: Glucagon-Like Peptide-1 Receptor*/agonists, Humans ; Animals ; Glucagon-Like Peptides/therapeutic use ; Glucagon-Like Peptides/pharmacology ; Vaccines/therapeutic use ; Vaccines/immunology ; Signal Transduction/drug effects ; Vaccination ; Glucagon-Like Peptide 1/immunology ; Glucagon-Like Peptide 1/therapeutic use
مستخلص: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide (Ozempic®), have emerged as effective treatments for diabetes and weight management. However, recent evidence indicates that GLP-1R signalling influences various tissues, including the immune system. Notably, GLP-1 has a short half-life (< 5 minutes) and exists in the picomolar range, while GLP-1RAs like semaglutide have extended half-lives of several days and are administered at supraphysiological doses. This review explores the potential impact of these medications on vaccine efficacy. We examine evidence suggesting that GLP-1RAs may attenuate vaccine responses through direct effects on immune cells and modulation of other tissues. Additionally, we discuss how GLP-1R signalling may create a tolerogenic environment, potentially reducing vaccine immunogenicity. Given the widespread use of GLP-1RAs, it is crucial to understand their impact on immune responses and the translational implications for vaccination outcomes.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Glucagon-like peptide 1; Immunosuppressive; Inflammation; Semaglutide; Vaccination
المشرفين على المادة: 0 (Glucagon-Like Peptide-1 Receptor)
53AXN4NNHX (semaglutide)
62340-29-8 (Glucagon-Like Peptides)
0 (Vaccines)
89750-14-1 (Glucagon-Like Peptide 1)
تواريخ الأحداث: Date Created: 20240718 Date Completed: 20240817 Latest Revision: 20240817
رمز التحديث: 20240818
DOI: 10.1016/j.cytogfr.2024.07.006
PMID: 39025754
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0305
DOI:10.1016/j.cytogfr.2024.07.006