دورية أكاديمية
أعرض في EDS

Therapy-Associated Saliva and Taste change Evaluation (TASTE) in head & neck cancer patients undergoing radiotherapy: a study protocol.

التفاصيل البيبلوغرافية
العنوان: Therapy-Associated Saliva and Taste change Evaluation (TASTE) in head & neck cancer patients undergoing radiotherapy: a study protocol.
المؤلفون: Dietze A; Center for Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, Switzerland.; Department of Radiation Oncology, Bern University Hospital and University of Bern, Inselspital, Bern, Switzerland., Neyer PJ; Institute of Laboratory Medicine, Cantonal Hospital Aarau, Aarau, Switzerland., Speth MM; Department of Otorhinolaryngology, Cantonal Hospital Aarau, Aarau, Switzerland., Metzler P; Department of Oral- and Maxillofacial Surgery, Cantonal Hospital Aarau, Aarau, Switzerland.; University of Zurich, Zurich, Switzerland., Elicin O; Department of Radiation Oncology, Bern University Hospital and University of Bern, Inselspital, Bern, Switzerland., Balermpas P; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Aebersold DM; Department of Radiation Oncology, Bern University Hospital and University of Bern, Inselspital, Bern, Switzerland., Riesterer O; Center for Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, Switzerland., Stieb S; Center for Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, Switzerland. sonja.stieb@ksa.ch.
المصدر: BMC cancer [BMC Cancer] 2024 Jul 18; Vol. 24 (1), pp. 865. Date of Electronic Publication: 2024 Jul 18.
نوع المنشور: Journal Article; Multicenter Study; Observational Study
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Head and Neck Neoplasms*/radiotherapy , Quality of Life* , Saliva*/radiation effects , Saliva*/metabolism , Taste* , Taste Disorders*/etiology , Taste Disorders*/diagnosis, Female ; Humans ; Male ; Prospective Studies ; Radiation Injuries/etiology ; Radiotherapy/adverse effects ; Surveys and Questionnaires ; Xerostomia/etiology ; Xerostomia/diagnosis
مستخلص: Background: One of the main side effects of radiation therapy to the head and neck region is altered taste sensation. This causes significant morbidity and has profound effects on the quality of life (QoL) of patients. While radiation-associated toxicities like xerostomia and dysphagia are part of large investigations, data on taste impairment is sparse. Small cohort sizes in the majority of studies and a variety of analysis methods limit our current understanding of the underlying processes. None of the studies published to date used a taste-specific QoL questionnaire with differentiation of the different taste qualities (e.g. sour, bitter). Furthermore, data regarding the correlation of taste impairment with radiation-associated change in saliva composition is currently not available. The aim of the TASTE study is to fill this gap. Based on the acquired data, a normal tissue complication probability (NTCP) model for late radiation-associated taste impairment will be developed.
Methods: In this prospective, observational multicenter study 150 head and neck cancer patients undergoing radiation therapy will be recruited and undergo repetitive (semi-) objective and subjective assessment of their taste, smell and salivary function (questionnaires, taste and smell assessment, saliva analysis). Primary endpoint will be patient-reported taste impairment 12 months post radiation therapy using a standardized questionnaire. Secondary endpoints will include taste impairment measured using taste strips at 12 months and 2 years post radiation therapy. Differences between subgroups (radiation side, chemotherapy, etc.) and changes over time will be assessed while adjusting for confounding factors (e.g. age, sex, smoking history).
Discussion: This study sets out to further our understanding of taste impairment in patients undergoing radiation therapy to the head and neck region with the goal to prevent this common side effect in future patients. The results of the study may be used to evaluate taste-preserving radiotherapy for patients with head and neck cancer, which may significantly reduce the long-term burden in this patient cohort.
(© 2024. The Author(s).)
References: J Physiol. 1972 Feb;220(3):529-45. (PMID: 5016036)
Radiother Oncol. 2021 Apr;157:63-69. (PMID: 33217499)
Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):991-7. (PMID: 7107441)
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):354-361. (PMID: 27473816)
Radiother Oncol. 2024 Jul;196:110279. (PMID: 38648994)
Laryngoscope. 2008 Jan;118(1):24-31. (PMID: 17975512)
Head Neck. 2007 Oct;29(10):923-31. (PMID: 17358040)
Auris Nasus Larynx. 2004 Dec;31(4):401-6. (PMID: 15571914)
J Oral Rehabil. 2007 Oct;34(10):711-23. (PMID: 17824883)
Sci Rep. 2021 Jun 10;11(1):12283. (PMID: 34112869)
Radiat Oncol. 2020 Jun 5;15(1):144. (PMID: 32503643)
J Neurosci. 2012 Mar 7;32(10):3474-84. (PMID: 22399770)
J Pharm Bioallied Sci. 2014 Jul;6(Suppl 1):S30-3. (PMID: 25210380)
Oral Oncol. 2018 Aug;83:25-31. (PMID: 30098775)
BDJ Open. 2017 Jun 30;3:17015. (PMID: 29607085)
Cancer Treat Rev. 2006 Nov;32(7):541-7. (PMID: 16887272)
Clin Oncol (R Coll Radiol). 1995;7(3):173-8. (PMID: 7547520)
Acta Oncol. 2022 Feb;61(2):146-152. (PMID: 35060430)
Radiology. 1982 Jul;144(1):163-9. (PMID: 7089250)
Radiother Oncol. 2020 Sep;150:97-103. (PMID: 32544605)
Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1422-9. (PMID: 17084561)
Radiother Oncol. 2021 Apr;157:147-154. (PMID: 33545258)
Br J Cancer Suppl. 1986;7:9-11. (PMID: 3459546)
Oral Dis. 2018 Nov;24(8):1399-1416. (PMID: 29645367)
Fukuoka Igaku Zasshi. 2002 Apr;93(4):64-76. (PMID: 12048909)
Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1107-14. (PMID: 27354125)
J Neurol. 2009 Feb;256(2):242-8. (PMID: 19221845)
Clin Transl Radiat Oncol. 2020 Mar 24;22:98-105. (PMID: 32373720)
Laryngoscope. 2000 Jan;110(1):98-106. (PMID: 10646723)
Arch Oral Biol. 2017 Oct;82:286-292. (PMID: 28686983)
Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Jun;133(3):203-6. (PMID: 26344139)
Chem Senses. 2019 May 29;44(5):319-326. (PMID: 30957861)
J Natl Cancer Inst Monogr. 2019 Aug 1;2019(53):. (PMID: 31425600)
Cancer. 2014 Jul 1;120(13):1975-84. (PMID: 24711162)
Sci Transl Med. 2015 Sep 16;7(305):305ra147. (PMID: 26378247)
Front Physiol. 2017 Mar 08;8:134. (PMID: 28337150)
Radiother Oncol. 2002 May;63(2):195-201. (PMID: 12063009)
Strahlenther Onkol. 2008 Mar;184(3):157-62. (PMID: 18330512)
Head Neck. 2006 Jun;28(6):508-16. (PMID: 16619275)
Strahlenther Onkol. 2002 Dec;178(12):722-6. (PMID: 12491061)
معلومات مُعتمدة: KFS 5681-08-2022 Swiss Cancer Research Foundation
فهرسة مساهمة: Keywords: Head and neck cancer; Quality of life; Radiotherapy; Saliva; Taste impairment; Taste qualities; Xerostomia
تواريخ الأحداث: Date Created: 20240718 Date Completed: 20240719 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11264495
DOI: 10.1186/s12885-024-12497-y
PMID: 39026163
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2407
DOI:10.1186/s12885-024-12497-y