دورية أكاديمية
أعرض في EDS

Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.
المؤلفون: Alarcón-Sánchez MA; Biomedical Science, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, 39090, Mexico. marioaasanchez@hotmail.com., Becerra-Ruiz JS; Institute of Research of Bioscience, University Center of Los Altos, University of Guadalajara, Tepatitlán de Morelos, Jalisco, 47600, Mexico., Avetisyan A; Department of Therapeutic Stomatology, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. Koryun 2, Yerevan, 0025, Armenia., Heboyan A; Department of Research Analytics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, 600 077, India. heboyan.artak@gmail.com.; Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. Koryun 2, Yerevan, 0025, Armenia. heboyan.artak@gmail.com.; Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, North Karegar St, Tehran, Iran. heboyan.artak@gmail.com.
المصدر: BMC oral health [BMC Oral Health] 2024 Jul 18; Vol. 24 (1), pp. 816. Date of Electronic Publication: 2024 Jul 18.
نوع المنشور: Journal Article; Systematic Review; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Dental Caries*/metabolism , Saliva*/chemistry , Saliva*/metabolism , Interleukin-6*/analysis , Interleukin-6*/metabolism , Interleukin-8*/analysis , Interleukin-8*/metabolism , Tumor Necrosis Factor-alpha*/analysis , Tumor Necrosis Factor-alpha*/metabolism, Humans ; Child ; Young Adult ; Adolescent ; Biomarkers/analysis
مستخلص: Background: Cytokines play an important role in the immunopathogenesis of dental caries. A systematic review and meta-analysis was carried out with the following three objectives: 1)To deepen and discuss through a comprehensive analysis of the literature the effects of dental caries on the activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults, 2)To compare the levels of this cytokines in saliva of the exposure group (moderate-severe dental caries) with the control group (caries-free or mild dental caries), and 3)To determine whether the levels of these cytokines could be used as a complementary clinical diagnostic tool to assess the severity of dental caries.
Methods: The protocol followed PRISMA and Cochrane guidelines and was registered in the Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/MF74V . A digital search was performed in PubMed/MEDLINE, Cochrane, Scopus, and Google Schoolar databases from February 15th, 2012, to January 13th, 2024. The methodological validity of the selected studies was assessed using Joanna Briggs Institute (JBI) tool. A meta-analysis was performed using a random-effects model to evaluate the association between dental caries/health, and the concentration of TNF-α, IL-6 and IL-8.
Results: The search strategy provided a total of 126 articles, of which 15 investigations met the inclusion criteria. The total number of patients studied was 1,148, of which 743 represented the case/exposure group, and 405 represented the control group. The age of the patients ranged from 3 to 25 years. IL-6 was the most prevalent cytokine in the saliva of children and young adults with active dental caries. The meta-analysis revealed that there are significant differences between the levels of IL-6 and TNF-α in saliva of children with active dental caries compared to their control groups.
Conclusions: The findings suggest that IL-6 and TNF-α levels may have potential as complementary biomarkers for assessing dental caries severity. However, further research is needed to validate these findings in larger and more diverse populations before clinical application.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Biomarkers; Dental caries; Interleukin-6; Interleukin-8; Saliva; Systematic review; Tumor necrosis factor- alpha
المشرفين على المادة: 0 (Interleukin-6)
0 (Interleukin-8)
0 (Tumor Necrosis Factor-alpha)
0 (CXCL8 protein, human)
0 (IL6 protein, human)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240718 Date Completed: 20240719 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11264839
DOI: 10.1186/s12903-024-04560-8
PMID: 39026257
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6831
DOI:10.1186/s12903-024-04560-8