دورية أكاديمية
Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function.
| العنوان: | Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function. |
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| المؤلفون: | Paddar MA; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Wang F; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Trosdal ES; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Hendrix E; Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM, USA., He Y; Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM, USA., Salemi M; Proteomics Core Facility, UC Davis Genome Center, University of California, Davis, CA 95616, USA., Mudd M; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Jia J; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Duque TLA; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Javed R; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA., Phinney B; Proteomics Core Facility, UC Davis Genome Center, University of California, Davis, CA 95616, USA., Deretic V; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence.; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA.; Lead Contact. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 12. Date of Electronic Publication: 2024 Jul 12. |
| نوع المنشور: | Journal Article; Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number of biological outputs includes control of tuberculosis in animal models. Here we show that ATG5 associates with retromer's core components VPS26, VPS29 and VPS35 and modulates retromer function. Knockout of ATG5 blocked trafficking of a key glucose transporter sorted by the retromer, GLUT1, to the plasma membrane. Knockouts of other genes essential for membrane atg8ylation, of which ATG5 is a component, affected GLUT1 sorting, indicating that membrane atg8ylation as a process affects retromer function and endosomal sorting. The contribution of membrane atg8ylation to retromer function in GLUT1 sorting was independent of canonical autophagy. These findings expand the scope of membrane atg8ylation to specific sorting processes in the cell dependent on the retromer and its known interactors. |
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| معلومات مُعتمدة: | P20 GM121176 United States GM NIGMS NIH HHS; R01 AI111935 United States AI NIAID NIH HHS; R37 AI042999 United States AI NIAID NIH HHS; S10 OD021801 United States OD NIH HHS |
| تواريخ الأحداث: | Date Created: 20240719 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| مُعرف محوري في PubMed: | PMC11257513 |
| DOI: | 10.1101/2024.07.10.602886 |
| PMID: | 39026874 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2692-8205 |
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| DOI: | 10.1101/2024.07.10.602886 |