دورية أكاديمية
أعرض في EDS

The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates.

التفاصيل البيبلوغرافية
العنوان: The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates.
المؤلفون: da Rosa EEB; Laboratório de Bioinformática (Omixlab), Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Rio Grande Do Sul, Brazil., Kremer FS; Laboratório de Bioinformática (Omixlab), Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Rio Grande Do Sul, Brazil. fred.s.kremer@gmail.com.
المصدر: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2024 Jul 19. Date of Electronic Publication: 2024 Jul 19.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : Switzerland, AG : Springer International Publishing
Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia
مستخلص: The increasing frequency of antibiotic-resistant bacteria is a constant threat to global human health. Therefore, the pathogens of the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Enterobacter spp.) are among the most relevant causes of hospital infections responsible for millions of deaths every year. However, little has been explored about the danger of microorganisms resistant to biocides such as antiseptics and disinfectants. Widely used in domestic, industrial, and hospital environments, these substances reach the environment and can cause selective pressure for resistance genes and induce cross-resistance to antibiotics, further aggravating the problem. Therefore, it is necessary to use innovative and efficient strategies to monitor the spread of genes related to resistance to biocides. Whole genome sequencing and bioinformatics analysis aiming to search for sequences encoding resistance mechanisms are essential to help monitor and combat these pathogens. Thus, this work describes the construction of a bioinformatics tool that integrates different databases to identify gene sequences that may confer some resistance advantage about biocides. Furthermore, the tool analyzed all the genomes of Brazilian ESKAPE isolates deposited at NCBI and found a series of different genes related to resistance to benzalkonium chloride, chlorhexidine, and triclosan, which were the focus of this work. As a result, the presence of resistance genes was identified in different types of biological samples, environments, and hosts. Regarding mobile genetic elements (MGEs), around 52% of isolates containing genes related to resistance to these compounds had their genes identified in plasmids, and 48.7% in prophages. These data show that resistance to biocides can be a silent, underestimated danger spreading across different environments and, therefore, requires greater attention.
(© 2024. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
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معلومات مُعتمدة: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Antibiotic resistance genes; Bioinformatics; Disinfectants; Horizontal gene transfer; Microbial genomics
تواريخ الأحداث: Date Created: 20240719 Latest Revision: 20240719
رمز التحديث: 20240719
DOI: 10.1007/s42770-024-01450-7
PMID: 39028534
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4405
DOI:10.1007/s42770-024-01450-7