دورية أكاديمية
Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer's disease.
| العنوان: | Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer's disease. |
|---|---|
| المؤلفون: | Hari E; Graduate School of Health Sciences, Istanbul University, 34216 Istanbul, Turkey; Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: emrehr@hotmail.com., Ulasoglu-Yildiz C; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: cigdemulasoglu@gmail.com., Kurt E; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: elifkurt@istanbul.edu.tr., Bayram A; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: ali.bayram@istanbul.edu.tr., Gurvit H; Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey. Electronic address: gurvit@istanbul.edu.tr., Demiralp T; Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: demiralp@istanbul.edu.tr. |
| المصدر: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2024 Sep; Vol. 165, pp. 127-137. Date of Electronic Publication: 2024 Jul 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100883319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8952 (Electronic) Linking ISSN: 13882457 NLM ISO Abbreviation: Clin Neurophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, c1999- |
| مواضيع طبية MeSH: | Alzheimer Disease*/physiopathology , Alzheimer Disease*/diagnostic imaging , Thalamic Nuclei*/physiopathology , Thalamic Nuclei*/diagnostic imaging , Magnetic Resonance Imaging* , Cognitive Dysfunction*/physiopathology , Cognitive Dysfunction*/diagnostic imaging, Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Middle Aged |
| مستخلص: | Objective: Memory processes known to be impaired in Alzheimer's disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages. Methods: MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used. Volumetric and functional connectivity analyzes were performed by dividing the thalamus into anterior, medial, posterior, lateral and intralaminar nucleus groups and their specific subnuclei. Results: In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. Medial group nuclei and MDm functional connectivity with frontal areas were decreased both in ADD and MCI compared to SCI group, while both of them increased their functional connectivity with visual areas in the ADD group compared to the MCI group. Conclusions: Our study suggests that the medial group of the thalamus, and specifically the MDm, may be affected in AD. Significance: Specific thalamic nuclei may be a critical anatomical region for investigating structural and functional changes in AD. (Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; Functional connectivity; Functional magnetic resonance imaging; Thalamic Nuclei; Volumetric analysis |
| تواريخ الأحداث: | Date Created: 20240719 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1016/j.clinph.2024.06.018 |
| PMID: | 39029273 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1872-8952 |
|---|---|
| DOI: | 10.1016/j.clinph.2024.06.018 |