دورية أكاديمية
Abnormalities in static and dynamic intrinsic neural activity and neurotransmitters in first-episode OCD.
| العنوان: | Abnormalities in static and dynamic intrinsic neural activity and neurotransmitters in first-episode OCD. |
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| المؤلفون: | Tao Q; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Dang J; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Guo H; Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, China., Zhang M; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Niu X; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Kang Y; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Sun J; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Ma L; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Wei Y; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Wang W; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Wen B; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China., Cheng J; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China. Electronic address: fccchengjl@zzu.edu.cn., Han S; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China. Electronic address: ShaoqiangHan@163.com., Zhang Y; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China. Electronic address: zzuzhangyong2013@163.com. |
| المصدر: | Journal of affective disorders [J Affect Disord] 2024 Jul 17. Date of Electronic Publication: 2024 Jul 17. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مستخلص: | Background: Obsessive-compulsive disorder (OCD) is a disabling disorder in which the temporal variability of regional brain connectivity is not well understood. The aim of this study was to investigate alterations in static and dynamic intrinsic neural activity (INA) in first-episode OCD and whether these changes have the potential to reflect neurotransmitters. Methods: A total of 95 first-episode OCD patients and 106 matched healthy controls (HCs) were included in this study. Based on resting-state functional magnetic resonance imaging (rs-fMRI), the static and dynamic local connectivity coherence (calculated by static and dynamic regional homogeneity, sReHo and dReHo) were compared between the two groups. Furthermore, correlations between abnormal INA and PET- and SPECT-derived maps were performed to examine specific neurotransmitter system changes underlying INA abnormalities in OCD. Results: Compared with HCs, OCD showed decreased sReHo and dReHo values in left superior, middle temporal gyrus (STG/MTG), left Heschl gyrus (HES), left putamen, left insula, bilateral paracentral lobular (PCL), right postcentral gyrus (PoCG), right precentral gyrus (PreCG), left precuneus and right supplementary motor area (SMA). Decreased dReHo values were also found in left PoCG, left PreCG, left SMA and left middle cingulate cortex (MCC). Meanwhile, alterations in INA present in brain regions were correlated with dopamine system (D2, FDOPA), norepinephrine transporter (NAT) and the vesicular acetylcholine transporter (VAChT) maps. Conclusion: Static and dynamic INA abnormalities exist in first-episode OCD, having the potential to reveal the molecular characteristics. The results help to further understand the pathophysiological mechanism and provide alternative therapeutic targets of OCD. Competing Interests: Declaration of competing interest All authors declared no conflict of interests. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Intrinsic neural activity; Neurotransmitters; Obsessive-compulsive disorder; Regional homogeneity; Static and dynamic |
| تواريخ الأحداث: | Date Created: 20240719 Latest Revision: 20240719 |
| رمز التحديث: | 20240720 |
| DOI: | 10.1016/j.jad.2024.07.123 |
| PMID: | 39029696 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2024.07.123 |