دورية أكاديمية
أعرض في EDS

Design of pH-responsive molecularly imprinted polymer as a carrier for controlled and sustainable capecitabine release.

التفاصيل البيبلوغرافية
العنوان: Design of pH-responsive molecularly imprinted polymer as a carrier for controlled and sustainable capecitabine release.
المؤلفون: Guo Z; School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China., Zheng H; College of Chemistry, Jilin University, Changchun, 130012, China., Ma J; College of Chemistry, Jilin University, Changchun, 130012, China., Xu G; School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China. Electronic address: xgx@jlu.edu.cn., Jia Q; College of Chemistry, Jilin University, Changchun, 130012, China. Electronic address: jiaqiong@jlu.edu.cn.
المصدر: Analytica chimica acta [Anal Chim Acta] 2024 Aug 15; Vol. 1317, pp. 342881. Date of Electronic Publication: 2024 Jun 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Amsterdam.
مواضيع طبية MeSH: Capecitabine*/chemistry , Drug Carriers*/chemistry , Molecularly Imprinted Polymers*/chemistry, Hydrogen-Ion Concentration ; Humans ; Drug Liberation ; Antimetabolites, Antineoplastic/chemistry ; Delayed-Action Preparations/chemistry ; Cell Survival/drug effects ; Density Functional Theory ; Polymers/chemistry ; Polymers/chemical synthesis
مستخلص: A molecularly imprinting polymer (MIP) carrier with pH-responsivity was designed to construct a drug delivery system (DDS) focusing on controlled and sustainable capecitabine (CAPE) release. The pH-responsive characteristic was achieved by the functionalization of SiO 2 substrate with 4-formylphenylboronic acid, accompanied by the introduction of fluorescein isothiocyanate for the visualization of the intracellular localization of the nanocarrier. Experimental results indicated that CAPE was adsorbed onto the drug carrier with satisfactory encapsulation efficiency. The controlled release of CAPE was realized based on the break of borate ester bonds between -B(OH) 2 and cis-diols in the weakly acidic environment. Density functional theory computations were conducted to investigate the adsorption/release mechanism. Moreover, in vitro experiments confirmed the good biocompatibility and ideal inhibition efficiency of the developed DDS. The MIP can act as an eligible carrier and exhibits the great potential in practical applications for tumor treatment.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Controlled/sustainable release; Density functional theory; Molecularly imprinting polymers; pH-responsive
المشرفين على المادة: 6804DJ8Z9U (Capecitabine)
0 (Drug Carriers)
0 (Molecularly Imprinted Polymers)
0 (Antimetabolites, Antineoplastic)
0 (Delayed-Action Preparations)
0 (Polymers)
تواريخ الأحداث: Date Created: 20240719 Date Completed: 20240719 Latest Revision: 20240719
رمز التحديث: 20240720
DOI: 10.1016/j.aca.2024.342881
PMID: 39029999
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4324
DOI:10.1016/j.aca.2024.342881