دورية أكاديمية
أعرض في EDS

The use of a protein network analysis to explore the complexity of early skin inflammation after oronasal mask application- A pilot study.

التفاصيل البيبلوغرافية
العنوان: The use of a protein network analysis to explore the complexity of early skin inflammation after oronasal mask application- A pilot study.
المؤلفون: Feldt A; Department of Acute Internal Medicine and Geriatrics in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, 581 83, Linköping, SE, Sweden. Amanda.feldt@liu.se., Ghafouri B; Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Worsley PR; Skin Sensing Research Group, School of Health Sciences, University of Southampton, Southampton, UK., Bergstrand S; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
المصدر: Scientific reports [Sci Rep] 2024 Jul 19; Vol. 14 (1), pp. 16691. Date of Electronic Publication: 2024 Jul 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Skin*/metabolism , Skin*/pathology , Masks*/adverse effects, Humans ; Male ; Female ; Pilot Projects ; Middle Aged ; Adult ; Protein Interaction Maps ; Cytokines/metabolism ; Inflammation/metabolism ; Aged ; Biomarkers ; Pressure Ulcer/etiology ; Wound Healing
مستخلص: Medical devices, such as non-invasive ventilation masks, save lives in health care settings but can be a cause of tissue injuries due to the pressure and shear loads on skin and soft tissue. These pressure injuries could be painful for the individual and cause a significant economic impact on healthcare providers. In the etiology of device related pressure ulcers, inflammation plays an important role. However, the exact nature and timing of inflammatory biomarker upregulation is still unknown in the early stages of skin damage. This study aimed to explore the inflammatory profile of vulnerable skin sites following non-invasive mask application on a convenience sample of eleven hospital patients. Seventy-one inflammatory proteins were explored from sebum sampled at the skin surface after oronasal mask application. A multivariate analysis to investigate differences between loaded and control site was conducted, with a protein network analysis used to explore interactions in the early inflammation. The study revealed that 21 cytokines and chemokines were important for the separation between loaded and control site. These proteins were associated with remodeling of tissue, vascular wound healing and/or cell death.
(© 2024. The Author(s).)
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معلومات مُعتمدة: RÖ-987649 Region Östergötland; 2020-01704 Vetenskapsrådet
المشرفين على المادة: 0 (Cytokines)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240719 Date Completed: 20240719 Latest Revision: 20240805
رمز التحديث: 20240805
مُعرف محوري في PubMed: PMC11271608
DOI: 10.1038/s41598-024-67583-9
PMID: 39030436
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-67583-9