دورية أكاديمية
أعرض في EDS

Mediation of depressive symptoms in the association between blood urea nitrogen to creatinine ratio and cognition among middle-aged and elderly adults: evidence from a national longitudinal cohort study.

التفاصيل البيبلوغرافية
العنوان: Mediation of depressive symptoms in the association between blood urea nitrogen to creatinine ratio and cognition among middle-aged and elderly adults: evidence from a national longitudinal cohort study.
المؤلفون: Feng Q; The Second Clinical College of Guangzhou, University of Chinese Medicine, Guangzhou, China., Yang S; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Ye S; The Second Clinical College of Guangzhou, University of Chinese Medicine, Guangzhou, China., Wan C; Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Wang H; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., You J; Department of Cerebrovascular Disease, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. youjs73@163.com.
المصدر: BMC psychiatry [BMC Psychiatry] 2024 Jul 19; Vol. 24 (1), pp. 515. Date of Electronic Publication: 2024 Jul 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Depression*/blood , Depression*/psychology , Creatinine*/blood , Cognition*/physiology , Blood Urea Nitrogen*, Humans ; Male ; Longitudinal Studies ; Female ; Aged ; Middle Aged ; China/epidemiology ; Mediation Analysis ; Cognitive Dysfunction/blood
مستخلص: Background: The relationships between BUNCr (blood urea nitrogen and creatinine ratio) and cognitive function, as well as depressive symptoms, remain unclear. We aim to investigate the association between BUNCr and cognition, as well as depressive symptoms, and to identify the mechanisms underlying these relationships.
Methods: We utilized data from the China Health and Retirement Longitudinal Study (CHARLS) from 2015 to 2020. Cognitive function was assessed using the Telephone Interview of Cognitive Status (TICS) scale, while depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale (CES-D-10). We employed multivariate linear regression models to examine the association between BUNCr and cognitive function, as well as depressive symptoms. Additionally, causal mediation analysis was conducted to identify potential mediation effects of depressive symptoms between BUNCr and cognition.
Results: We observed a negative association between BUNCr and cognitive function (coefficient: -0.192; 95% confidence interval [CI]: -0.326 ∼ -0.059) and a positive relationship between BUNCr and depressive symptoms (coefficient: 0.145; 95% CI: 0.006 ∼ 0.285). In addition, the causal mediation analysis revealed that depressive symptoms (proportion mediated: 7.0%) significantly mediated the association between BUNCr and cognition.
Conclusion: Our study has unveiled that BUNCr is inversely associated with cognitive function and positively linked to depressive symptoms. Moreover, we found that depressive symptoms significantly mediated the association between BUNCr and cognition. These findings provide new evidence and insights for the prevention and management of cognitive function and dementia.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 81774055 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Blood urea nitrogen; Cognition; Creatinine; Depressive symptoms; Mediation
المشرفين على المادة: AYI8EX34EU (Creatinine)
تواريخ الأحداث: Date Created: 20240719 Date Completed: 20240720 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11264492
DOI: 10.1186/s12888-024-05941-7
PMID: 39030588
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-244X
DOI:10.1186/s12888-024-05941-7