دورية أكاديمية
Preparation, characterization, and liver targeting evaluation of a novel sustained-release brucine self-assembled micelle mediated by glycyrrhetinic acid.
| العنوان: | Preparation, characterization, and liver targeting evaluation of a novel sustained-release brucine self-assembled micelle mediated by glycyrrhetinic acid. |
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| المؤلفون: | Guan Q; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Yang H; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Xia Z; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Li X; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Zhang Y; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Lin Z; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Sun S; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Yang Z; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Zhou X; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Lv S; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China., Wang Y; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, 24 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China. |
| المصدر: | Journal of biomaterials applications [J Biomater Appl] 2024 Oct; Vol. 39 (4), pp. 317-331. Date of Electronic Publication: 2024 Jul 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: England NLM ID: 8813912 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-8022 (Electronic) Linking ISSN: 08853282 NLM ISO Abbreviation: J Biomater Appl Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : London : Sage Publications Original Publication: Lancaster, PA : Technomic Pub. Co., Inc., [c1986- |
| مواضيع طبية MeSH: | Micelles* , Glycyrrhetinic Acid*/chemistry , Glycyrrhetinic Acid*/analogs & derivatives , Glycyrrhetinic Acid*/pharmacokinetics , Strychnine*/analogs & derivatives , Strychnine*/pharmacokinetics , Strychnine*/chemistry , Strychnine*/administration & dosage , Delayed-Action Preparations*/chemistry , Liver*/metabolism , Drug Carriers*/chemistry, Animals ; Humans ; Male ; Drug Liberation ; Rats, Sprague-Dawley ; Rats ; Particle Size ; Mice ; Biological Availability ; Tissue Distribution |
| مستخلص: | Background: Cancer is a serious threat to human life, health and social development. In recent years, nanomicelles, as an emerging drug carrier material, have gradually entered people's field of vision because of their advantages of improving bioavailability, maintaining drug levels, reducing systemic side effects and increasing drug accumulation at target sites. Methods: In this study, B-GPSG nano-micelles were prepared by film dispersion hydration method using brucine as model drug and glycyrrhetinic acid-polyethylene glycol-3-methylene glycol-dithiodipropionic acid-glycerol monostearate polymer as nano-carrier. The preparation process, characterization, drug release in vitro, pharmacokinetics and liver targeting were investigated. Results: The results showed that the range of particle size, polydispersion index and Zeta potential were 102.7 ± 1.09 nm, 0.201 ± 0.02 and -24.5 ± 0.19 mV respectively. The entrapment efficiency and drug loading were 83.79 ± 2.13% and 12.56 ± 0.09%, respectively. The drug release experiments in vitro and pharmacokinetic experiments showed that it had obvious sustained release effect. For pharmacokinetics study, it shows that both the B-GPSG solution group and the B-PSG solution group changed the metabolic kinetic parameters of brucine, but the B-GPSG solution group had a better effect. Compared with the B-PSG solution group, the drug was more prolonged in rats. The half-life in the body and the retention time in the body of B-GPSG are more helpful to improve the bioavailability of the drug and play a long-term effect. The tail vein injection results of mice indicate that B-GPSG can target and accumulate brucine in the liver without affecting other key organs. Cell uptake experiments and tissue distribution experiments in vivo show that glycyrrhetinic acid modified nano-micelles can increase the accumulation of brucine in hepatocytes, has a good liver targeting effect, and can be used as a new preparation for the treatment of liver cancer. Conclusion: The B-SPSG prepared in this experiment can provide a new treatment method and research idea for the treatment of liver cancer. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: Brucine; drug release in vitro; glycyrrhetinic acid; liver targeting; nano-micelles; pharmacokinetics |
| المشرفين على المادة: | 6NG17YCK6H (brucine) 0 (Micelles) P540XA09DR (Glycyrrhetinic Acid) H9Y79VD43J (Strychnine) 0 (Delayed-Action Preparations) 0 (Drug Carriers) |
| تواريخ الأحداث: | Date Created: 20240720 Date Completed: 20240827 Latest Revision: 20240827 |
| رمز التحديث: | 20240827 |
| DOI: | 10.1177/08853282241258161 |
| PMID: | 39031074 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1530-8022 |
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| DOI: | 10.1177/08853282241258161 |