دورية أكاديمية
The MindMoves Trial: Cross-Sectional Analyses of Baseline Vascular Risk and Cognition in Older Women with Cardiovascular Disease.
| العنوان: | The MindMoves Trial: Cross-Sectional Analyses of Baseline Vascular Risk and Cognition in Older Women with Cardiovascular Disease. |
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| المؤلفون: | Halloway S; College of Nursing, University of Illinois Chicago, Chicago, IL, USA., Volgman AS; Rush Medical College, Rush University, Chicago, IL, USA., Barnes LL; Rush Medical College, Rush University, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Schoeny ME; Rush University College of Nursing, Rush University, Chicago, IL, USA., Wilbur J; Rush University College of Nursing, Rush University, Chicago, IL, USA., Pressler SJ; Indiana University School of Nursing, Indiana University, IN, USA., Laddu D; Arbor Research Collaborative for Health, Ann Arbor, MI, USA., Phillips SA; College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA., Vispute S; Rush University College of Nursing, Rush University, Chicago, IL, USA., Hall G; Rush University College of Nursing, Rush University, Chicago, IL, USA., Shakya S; College of Nursing, University of Illinois Chicago, Chicago, IL, USA., Goodyke M; College of Nursing, University of Illinois Chicago, Chicago, IL, USA., Auger C; Rush Medical College, Rush University, Chicago, IL, USA., Cagin K; Rush Medical College, Rush University, Chicago, IL, USA., Borgia JA; Rush Medical College, Rush University, Chicago, IL, USA., Arvanitakis ZA; Rush Medical College, Rush University, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. |
| المصدر: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| مستخلص: | Background: Vascular diseases, including atherosclerotic cardiovascular disease (ASCVD) and stroke, increase the risk of Alzheimer's disease and cognitive impairment. Serum biomarkers, such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF-1), may be indicators of cognitive health. Objective: We examined whether vascular risk was associated with levels of cognition and serum biomarkers in older women with cardiovascular disease (CVD). Methods: Baseline data from a lifestyle trial in older women (n = 253) with CVD (NCT04556305) were analyzed. Vascular risk scores were calculated for ASCVD (ASCVD risk estimator) and stroke (CHA2DS2-VASc) based on published criteria. Cognition-related serum biomarkers included BDNF, VEGF, and IGF-1. Cognition was based on a battery of neuropsychological tests that assessed episodic memory, semantic memory, working memory, and executive function. A series of separate linear regression models were used to evaluate associations of vascular risk scores with outcomes of cognition and serum biomarkers. All models were adjusted for age, education level, and racial and ethnic background. Results: In separate linear regression models, both ASCVD and CHA2DS2-VASc scores were inversely associated with semantic memory (β= -0.22, p = 0.007 and β= -0.15, p = 0.022, respectively), with no significant findings for the other cognitive domains. There were no significant associations between vascular risk scores and serum biomarkers. Conclusions: Future studies should prospectively examine associations between vascular risk and cognition in other populations and additionally consider other serum biomarkers that may be related to vascular risk and cognition. |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; biomarkers; cardiovascular health; risk factors; stroke |
| تواريخ الأحداث: | Date Created: 20240720 Latest Revision: 20240720 |
| رمز التحديث: | 20240721 |
| DOI: | 10.3233/JAD-240100 |
| PMID: | 39031356 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-8908 |
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| DOI: | 10.3233/JAD-240100 |