دورية أكاديمية
أعرض في EDS

Stimulation of the calcium-sensing receptor induces relaxations through CGRP and NK1 receptor-mediated pathways in male rat mesenteric arteries.

التفاصيل البيبلوغرافية
العنوان: Stimulation of the calcium-sensing receptor induces relaxations through CGRP and NK1 receptor-mediated pathways in male rat mesenteric arteries.
المؤلفون: Carlton-Carew SRE; Vascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK., Greenberg HZE; Vascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK., Greenwood IA; Vascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK., Albert AP; Vascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK.
المصدر: Physiological reports [Physiol Rep] 2024 Jun; Vol. 12 (12), pp. e16125.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
مواضيع طبية MeSH: Receptors, Calcium-Sensing*/metabolism , Calcitonin Gene-Related Peptide*/metabolism , Calcitonin Gene-Related Peptide*/pharmacology , Receptors, Neurokinin-1*/metabolism , Mesenteric Arteries*/drug effects , Mesenteric Arteries*/physiology , Mesenteric Arteries*/metabolism , Vasodilation*/drug effects , Vasodilation*/physiology, Animals ; Male ; Rats ; Rats, Wistar ; Neurokinin-1 Receptor Antagonists/pharmacology ; Calcium/metabolism ; Capsaicin/pharmacology ; Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacology ; Signal Transduction/physiology
مستخلص: Stimulation of the calcium-sensing receptor (CaSR) regulates vascular contractility, but cellular mechanisms involved remain unclear. This study investigated the role of perivascular sensory nerves in CaSR-induced relaxations of male rat mesenteric arteries. In fluorescence studies, colocalisation between synaptophysin, a synaptic vesicle marker, and the CaSR was present in the adventitial layer of arterial segments. Using wire myography, increasing external Ca 2+ concentration ([Ca 2+ ] o ) from 1 to 10 mM induced vasorelaxations, previously shown to involve the CaSR, which were inhibited by pretreatment with capsaicin. [Ca 2+ ] o -induced vasorelaxations were partially reduced by the calcitonin gene-related peptide (CGRP) receptor blockers, CGRP 8-37 and BIBN 4096, and the neurokinin 1 (NK1) receptor blocker L733,060. The inhibitory effect of CGRP 8-37 required a functional endothelium whereas the inhibitory action of L733,060 did not. Complete inhibition of [Ca 2+ ] o -induced vasorelaxations occurred when CGRP 8-37 and L733,060 were applied together. [Ca 2+ ] o -induced vasorelaxations in the presence of capsaicin were abolished by the ATP-dependent K + channel (K ATP ) blocker PNU 37883, but unaffected by the endothelium nitric oxide synthase (eNOS) inhibitor L-NAME. We suggest that the CaSR on perivascular sensory nerves mediate relaxations in rat mesenteric arteries via endothelium-dependent and -independent mechanisms involving CGRP and NK1 receptor-activated NO production and K ATP channels, respectively.
(© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
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معلومات مُعتمدة: FS/13/10/30021 British Heart Foundation (BHF); FS/17/40/32942 British Heart Foundation (BHF); BB/J007226/1 UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
فهرسة مساهمة: Keywords: calcitonin gene‐related peptide; calcium‐sensing receptor; perivascular sensory nerves; substance P; vascular smooth muscle
المشرفين على المادة: 0 (Receptors, Calcium-Sensing)
JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
0 (Receptors, Neurokinin-1)
0 (Neurokinin-1 Receptor Antagonists)
SY7Q814VUP (Calcium)
S07O44R1ZM (Capsaicin)
0 (Calcitonin Gene-Related Peptide Receptor Antagonists)
تواريخ الأحداث: Date Created: 20240720 Date Completed: 20240720 Latest Revision: 20240722
رمز التحديث: 20240722
مُعرف محوري في PubMed: PMC11189779
DOI: 10.14814/phy2.16125
PMID: 39031618
قاعدة البيانات: MEDLINE
الوصف
تدمد:2051-817X
DOI:10.14814/phy2.16125