دورية أكاديمية
Predictive value of CXCL1 + _FAP + phenotype in CAFs for distant metastasis and its correlation with PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma patients.
| العنوان: | Predictive value of CXCL1 + _FAP + phenotype in CAFs for distant metastasis and its correlation with PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma patients. |
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| المؤلفون: | Wen YF; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: wenyf@gzhmu.edu.cn., Huang WJ; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: wenjin1123@sina.com., Chen XL; Department of Spinal and Spinal Cord Rehabilitation, Guangdong Province Work Injury Rehabilitation Hospital, Guangzhou Province, China. Electronic address: chenxiaolong_1980@126.com., Cai HT; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: 1464386428@qq.com., Zhang YB; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: 450519864@qq.com., Song XL; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: songxianlu@tom.com., Xie CB; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: xcb214338968@163.com., Peng HH; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: penghaihua@gzhmu.edu.cn., Yu HW; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: noveaie@163.com., Chen CC; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: chenchengcong@gzhmu.edu.cn., Wei LQ; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: wwwlq0815@163.com., Zhou TC; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: ztc19650407@163.com., Cai S; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: 315979559@qq.com., Wang F; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: wangfang@gzhmu.edu.cn., Lin XD; Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou Province, China. Electronic address: 2018684038@gzhmu.edu.cn. |
| المصدر: | Oral oncology [Oral Oncol] 2024 Oct; Vol. 157, pp. 106963. Date of Electronic Publication: 2024 Jul 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9709118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0593 (Electronic) Linking ISSN: 13688375 NLM ISO Abbreviation: Oral Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Oxford ; New York : Pergamon, c1997- |
| مواضيع طبية MeSH: | B7-H1 Antigen*/metabolism , Nasopharyngeal Carcinoma*/metabolism , Nasopharyngeal Carcinoma*/pathology , Nasopharyngeal Carcinoma*/mortality , Nasopharyngeal Neoplasms*/metabolism , Nasopharyngeal Neoplasms*/pathology , Nasopharyngeal Neoplasms*/mortality , Chemokine CXCL1*/metabolism , Cancer-Associated Fibroblasts*/metabolism, Humans ; Male ; Female ; Middle Aged ; Adult ; Retrospective Studies ; Neoplasm Metastasis ; Prognosis ; Phenotype ; Biomarkers, Tumor/metabolism ; Aged ; Serine Endopeptidases/metabolism ; Endopeptidases/metabolism ; Membrane Proteins/metabolism |
| مستخلص: | Objective: There is a lack of effective biomarkers for predicting the distant metastasis in nasopharyngeal carcinoma (NPC). We aimed to explore the expression of FAP + Cancer-associated fibroblasts (CAFs) derived CXCL1 in NPC and its predictive values for distant metastasis and correlation with PD-L1 expression. Materials and Methods: A total of 345 patients with locoregionally advanced NPC were retrospectively enrolled (the training cohort: the validation cohort = 160:185). Co-expression of CXCL1 and FAP and the expression of PD-L1 were detected by multi-immunofluorescence staining and immunohistochemistry, respectively. The primary end-point was distant metastasis-free survival (DMFS). The Kaplan-Meier method was used to calculate the survival. The Cox proportional hazards model was used to assess prognostic risk factors. Results: A novel CXCL1 + _FAP + phenotype in CAFs was identified in NPC and then used to divide patients into low and high risk groups. Both in the training cohort and validation cohort, patients in the high risk group had poorer DMFS, overall survival (OS), progression-free survival (PFS) and locoregional relapse-free survival (LRFS) than patients in the low risk group. Multivariate analysis revealed CXCL1 + _FAP + phenotype was an independent prognostic factor for DMFS, OS, PFS and LRFS. Further results showed patients in the high risk group had higher PD-L1 expression than those in the low risk group. Conclusion: Our study showed CXCL1 + _FAP + phenotype in CAFs could effectively classified locoregionally advanced NPC patients into different risk groups for distant metastasis and might be a potential biomarker for anti-PD-1/PD-L1 immunotherapy. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CXCL1; Cancer-associated fibroblasts; FAP; Metastasis; Nasopharyngeal carcinoma; PD-L1; Prognosis |
| المشرفين على المادة: | 0 (B7-H1 Antigen) 0 (CD274 protein, human) 0 (Chemokine CXCL1) 0 (CXCL1 protein, human) EC 3.4.21.- (fibroblast activation protein alpha) 0 (Biomarkers, Tumor) EC 3.4.21.- (Serine Endopeptidases) EC 3.4.- (Endopeptidases) 0 (Membrane Proteins) |
| تواريخ الأحداث: | Date Created: 20240720 Date Completed: 20240820 Latest Revision: 20240820 |
| رمز التحديث: | 20240821 |
| DOI: | 10.1016/j.oraloncology.2024.106963 |
| PMID: | 39032343 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-0593 |
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| DOI: | 10.1016/j.oraloncology.2024.106963 |