دورية أكاديمية
أعرض في EDS

HIV acute infection and long-term undisclosed HIV status among blood donors from the highly endemic Amazonas state, located in the Brazilian Amazon.

التفاصيل البيبلوغرافية
العنوان: HIV acute infection and long-term undisclosed HIV status among blood donors from the highly endemic Amazonas state, located in the Brazilian Amazon.
المؤلفون: Souza MIS; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, Brazil., Crispim MAE; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, Brazil., Fraiji NA; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, Brazil., Silva-Junior AL; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, Brazil., Stefani MMA; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, Brazil; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brazil. Electronic address: mmastefani@gmail.com.
المصدر: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2024 Jul-Aug; Vol. 28 (4), pp. 103848. Date of Electronic Publication: 2024 Jul 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Editora Country of Publication: Brazil NLM ID: 9812937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4391 (Electronic) Linking ISSN: 14138670 NLM ISO Abbreviation: Braz J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2010- : Rio de Janeiro : Elsevier Editora
Original Publication: Salvador, Bahia, Brazil : Contexto, c1997-
مواضيع طبية MeSH: Blood Donors*/statistics & numerical data , HIV Infections*/epidemiology , HIV Infections*/drug therapy , HIV Infections*/transmission, Humans ; Male ; Brazil/epidemiology ; Adult ; Female ; Young Adult ; Middle Aged ; Acute Disease ; Viral Load ; Adolescent ; Endemic Diseases ; CD4 Lymphocyte Count ; HIV-1/genetics ; Chronic Disease
مستخلص: Background: The Amazonas state/AM and Manaus rank among the highest AIDS detection rates in Brazil. High proportion of HIV infected blood donors and transmission clusters of multidrug antiretroviral/ARV resistant viruses were described in HEMOAM blood donors, a main Amazonas public blood bank. Recent and long-term infections among previously genotyped donors are reported.
Methods/materials: The recency immunoassay Lag Avidity EIA (Maxim, USA) was employed. Clinical/CD4/viral load medical file data of the main local HIV management center (FMT-HVD) and ARV treatment/ART data were reviewed.
Results: Among 142 HIV-blood donors, chronic infection predominated (n = 87; 61.3 %), 79 based on LAg EIA and 8 undisclosed HIV identified in FMT-HVD records, mostly young adult, single males, 4 repeat donors, all ART-naive. Recent infections represented 30.3 % (n = 43), 39 identified by LAg EIA and 4 immunologic windows (antibody negative/NAT/RNA positive). The overall profile of recent and long-term infections was similar, including moderate rate of transmitted drug resistance/TDR, however with multiple resistance mutations to more than one ARV-class, suggesting ART/failure.
Discussion: Recent/acute and undisclosed/long-term HIV infections represent blood safety alerts suggesting test-seeking behavior of at-risk populations. Early ART use in Brazil, can turn HIV diagnosis more challenging representing a blood transfusion risk in the highly endemic Brazilian Amazon.
Competing Interests: Conflicts of interest The authors certify that they have no financial or non-financial interest in the subject or materials discussed in this manuscript.
(Copyright © 2024. Published by Elsevier España, S.L.U.)
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فهرسة مساهمة: Keywords: Brazilian Amazon; HIV blood donors; HIV incidence
تواريخ الأحداث: Date Created: 20240720 Date Completed: 20240808 Latest Revision: 20240818
رمز التحديث: 20240818
مُعرف محوري في PubMed: PMC11327927
DOI: 10.1016/j.bjid.2024.103848
PMID: 39032516
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4391
DOI:10.1016/j.bjid.2024.103848