دورية أكاديمية
أعرض في EDS

Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure.

التفاصيل البيبلوغرافية
العنوان: Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure.
المؤلفون: Valencia N; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany. Electronic address: noel.valencia@med.uni-heidelberg.de., Seeger FR; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany., Seitz KI; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany., Carius L; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany., Nkrumah RO; Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany., Schmitz M; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany., Bertsch K; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany; German Center for Mental Health (DZPG), Partner Site Mannheim/Heidelberg/Ulm, Germany; Department of Psychology, Julius-Maximilians-University Wuerzburg, Marcusstr. 9-11, 97070, Wuerzburg, Germany., Herpertz SC; Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Voßstr. 2, 69115, Heidelberg, Germany; German Center for Mental Health (DZPG), Partner Site Mannheim/Heidelberg/Ulm, Germany.
المصدر: Journal of psychiatric research [J Psychiatr Res] 2024 Sep; Vol. 177, pp. 239-248. Date of Electronic Publication: 2024 Jul 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Pergamon Press
مواضيع طبية MeSH: Magnetic Resonance Imaging* , Default Mode Network*/physiopathology , Default Mode Network*/diagnostic imaging , Stress Disorders, Post-Traumatic*/physiopathology , Stress Disorders, Post-Traumatic*/diagnostic imaging , Depressive Disorder, Major*/physiopathology , Depressive Disorder, Major*/diagnostic imaging , Adult Survivors of Child Abuse* , Connectome*, Humans ; Female ; Male ; Adult ; Middle Aged ; Somatoform Disorders/physiopathology ; Somatoform Disorders/diagnostic imaging ; Young Adult ; Nerve Net/diagnostic imaging ; Nerve Net/physiopathology ; Time Factors ; Brain/physiopathology ; Brain/diagnostic imaging
مستخلص: Childhood maltreatment (CM) has been demonstrated to be associated with changes in resting-state functional connectivity of the default-mode network (DMN) across various mental disorders. Growing evidence regarding severity of CM is available but transdiagnostic research considering the role of both severity and duration of CM for DMN connectivity at rest is still scarce. We recruited a sample of participants with varying levels of CM suffering from three disorders in which a history of CM is frequently found, namely, post-traumatic stress disorder, major depressive disorder, or somatic symptom disorder, as well as healthy volunteers to examine DMN connectivity in a transdiagnostic sample. We expected to find changes in inter-network connectivity of the DMN related to higher self-reported levels of CM severity and duration. Resting-state functional magnetic resonance imaging scans of 128 participants were analyzed focusing on regions of interest (ROI-to-ROI approach) and whole-brain Seed-to-Voxel analyses with retrospectively assessed CM as predictor in a regression model. Changes in connectivity between nodes of the DMN and the visual network were identified to be associated with CM duration but not severity. CM duration showed associations with increased connectivity of the precuneus and visual regions, as well as sensory-motor regions. The observed changes in connectivity could be interpreted as an impairment of information transfer between the transmodal DMN and unimodal visual and sensory-motor regions with impairment increasing with duration of exposure to CM.
Competing Interests: Declaration of competing interest Declarations of interest: The authors have no conflicts of interest to disclose.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
التعليقات: Erratum in: J Psychiatr Res. 2024 Aug 8;178:77. doi: 10.1016/j.jpsychires.2024.08.009. (PMID: 39126878)
فهرسة مساهمة: Keywords: Childhood maltreatment; Default-mode network; Depression; Maltreatment duration; Post-traumatic stress disorder; Somatic symptom disorder
تواريخ الأحداث: Date Created: 20240721 Date Completed: 20240903 Latest Revision: 20240903
رمز التحديث: 20240904
DOI: 10.1016/j.jpsychires.2024.07.022
PMID: 39033670
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1379
DOI:10.1016/j.jpsychires.2024.07.022