دورية أكاديمية
أعرض في EDS

Novel insight into MDA-7/IL-24: A potent therapeutic target for autoimmune and inflammatory diseases.

التفاصيل البيبلوغرافية
العنوان: Novel insight into MDA-7/IL-24: A potent therapeutic target for autoimmune and inflammatory diseases.
المؤلفون: Feng K; Department of Pulmonary and Critical Care Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Disease of Sun Yat-sen University, Guangzhou, Guangdong Province 510630, China., Cen J; Department of Pulmonary and Critical Care Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Disease of Sun Yat-sen University, Guangzhou, Guangdong Province 510630, China., Zou X; Department of Pulmonary and Critical Care Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Disease of Sun Yat-sen University, Guangzhou, Guangdong Province 510630, China., Zhang T; Department of Pulmonary and Critical Care Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Disease of Sun Yat-sen University, Guangzhou, Guangdong Province 510630, China. Electronic address: zhtituli@163.com.
المصدر: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Sep; Vol. 266, pp. 110322. Date of Electronic Publication: 2024 Jul 20.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Orlando, FL : Academic Press, c1999-
مواضيع طبية MeSH: Interleukins*/immunology , Interleukins*/metabolism , Autoimmune Diseases*/immunology , Autoimmune Diseases*/therapy , Autoimmune Diseases*/drug therapy , Inflammation*/immunology, Humans ; Animals ; Signal Transduction ; Immunotherapy/methods
مستخلص: Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24) is a pleiotropic member of the IL-10 family of cytokines, and is involved in multiple biological processes, including cell proliferation, cell differentiation, tissue fibrosis, the inflammatory response, and antitumor activity. MDA-7/IL-24 can regulate epithelial integrity, homeostasis, mucosal immunity and host resistance to various pathogens by enhancing immune and inflammatory responses. Our recent study revealed the mechanism of MDA-7/IL-24 in promoting airway inflammation and airway remodeling through activating the JAK/STAT3 and ERK signaling pathways in bronchial epithelial cells. Herein, we summarize the cellular sources, inducers, target cells, signaling pathways, and biological effects of MDA-7/IL-24 in several allergic and autoimmune diseases. This review also synopsizes recent advances in clinical research targeting MDA-7/IL-24 or its receptors. Based on these advancements, we emphasize its potential as a target for immunotherapy and discuss the challenges of developing immunotherapeutic drugs targeting MDA-7/IL-24 or its receptors in autoimmune and inflammatory disorders.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Allergy; Autoimmune diseases; Inflammation; MDA-7/IL-24
المشرفين على المادة: 0 (interleukin-24)
0 (Interleukins)
تواريخ الأحداث: Date Created: 20240721 Date Completed: 20240816 Latest Revision: 20240926
رمز التحديث: 20240926
DOI: 10.1016/j.clim.2024.110322
PMID: 39033900
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-7035
DOI:10.1016/j.clim.2024.110322