دورية أكاديمية
أعرض في EDS

Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.

التفاصيل البيبلوغرافية
العنوان: Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.
المؤلفون: Lipman AR; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.; Columbia University Renal Epidemiology Group, New York, USA., Lytrivi ID; Division of Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons, New York, USA., Fernandez HE; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.; Division of Nephrology, Department of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons, New York, USA., Lynch AM; Division of Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons, New York, USA., Yu ME; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.; Columbia University Renal Epidemiology Group, New York, USA., Stevens JS; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.; Columbia University Renal Epidemiology Group, New York, USA., Mohan S; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.; Columbia University Renal Epidemiology Group, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA., Husain SA; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.; Columbia University Renal Epidemiology Group, New York, USA.
المصدر: Pediatric transplantation [Pediatr Transplant] 2024 Aug; Vol. 28 (5), pp. e14829.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997-
مواضيع طبية MeSH: Acute Kidney Injury*/etiology , Acute Kidney Injury*/epidemiology , Heart Transplantation* , Postoperative Complications*/epidemiology , Postoperative Complications*/etiology , Renal Dialysis*, Humans ; Male ; Female ; Retrospective Studies ; Child ; Child, Preschool ; Risk Factors ; Adolescent ; Infant
مستخلص: Background: Acute kidney injury (AKI) is a common complication of pediatric heart transplant, with a subset of patients developing severe AKI requiring dialysis (AKI-D). We aimed to identify the epidemiology, risk factors, and outcomes of postoperative AKI-D in pediatric heart transplant recipients.
Methods: We retrospectively identified all pediatric first-time, single-organ heart transplants at our institution from 2014 to 2022. Postoperative AKI was defined as AKI within 2 weeks of transplant. Unadjusted and adjusted logistic regression were used to identify characteristics associated with AKI-D, and unadjusted time-to-event analyses were used to determine the association between AKI-D and survival free of kidney failure.
Results: Among 177 patients included, 116 (66%) developed postoperative AKI of any stage, including 13 (7%) who developed AKI-D with median time from transplant to dialysis initiation of 6 days (IQR 3-13). In adjusted models, increased cardiopulmonary bypass time (OR 1.19, 95% CI 1.04-1.37, per 15 min increase in bypass time) and higher weight at transplant were associated with higher odds of AKI-D, whereas patient demographics and pretransplant kidney function were not associated with AKI-D. AKI-D was associated with greater mortality during initial hospitalization (46% vs. 1%, p < 0.001) and a lower rate of survival free of kidney failure.
Conclusions: The incidence of AKI-D after pediatric heart transplant was 7%, with extended cardiopulmonary bypass time associated with postoperative AKI-D even in adjusted models. Further research is needed to improve the prediction and management of AKI-D in this population.
(© 2024 Wiley Periodicals LLC.)
References: J Am Coll Cardiol. 2009 Jul 7;54(2):160-5. (PMID: 19573734)
Pediatr Int. 2017 Dec;59(12):1252-1260. (PMID: 28672079)
JAMA Pediatr. 2018 Mar 1;172(3):257-268. (PMID: 29356810)
Eur J Cardiothorac Surg. 1994;8(11):597-602. (PMID: 7893500)
Ann Thorac Surg. 2001 Aug;72(2):542-7. (PMID: 11515895)
Ann Card Anaesth. 2017 Jan-Mar;20(1):22-27. (PMID: 28074790)
Anesthesiology. 2023 Dec 1;139(6):880-898. (PMID: 37812758)
Kidney Int. 2023 Jun;103(6):1041-1055. (PMID: 37030663)
Am J Transplant. 2024 Feb;24(2S1):S305-S393. (PMID: 38431362)
Arch Dis Child. 2022 Jan;107(1):47-51. (PMID: 34140308)
Nephrol Dial Transplant. 2023 May 31;38(6):1560-1563. (PMID: 36646434)
J Clin Pharmacol. 2020 Dec;60(12):1551-1560. (PMID: 32542790)
Pediatr Crit Care Med. 2017 Jul;18(7):638-646. (PMID: 28492399)
Curr Opin Cardiol. 2002 Mar;17(2):152-9. (PMID: 11981247)
Anesthesiology. 2017 Feb;126(2):205-213. (PMID: 27906706)
J Clin Med. 2021 Sep 12;10(18):. (PMID: 34575227)
J Thorac Cardiovasc Surg. 1994 Jan;107(1):203-9. (PMID: 8283886)
Ann Thorac Surg. 2014 Jun;97(6):2142-7. (PMID: 24725832)
Pediatr Nephrol. 2022 Mar;37(3):509-519. (PMID: 34595570)
Front Pediatr. 2022 May 12;10:889958. (PMID: 35633961)
Pediatr Cardiol. 2024 Jan 13;:. (PMID: 38217691)
Clin Biochem. 2013 Sep;46(13-14):1244-51. (PMID: 23876402)
Kidney Int. 1996 Feb;49(2):314-26. (PMID: 8821813)
Pediatr Nephrol. 2023 Oct;38(10):3241-3251. (PMID: 36862250)
JAMA Netw Open. 2022 May 2;5(5):e2212709. (PMID: 35583867)
Transplantation. 2018 Nov;102(11):1901-1908. (PMID: 29979343)
Pediatr Transplant. 2020 Sep;24(6):e13753. (PMID: 32497381)
Circ Heart Fail. 2012 Jan;5(1):54-62. (PMID: 22167320)
Am J Kidney Dis. 2018 Dec;72(6):846-856. (PMID: 29866457)
Am J Transplant. 2018 Jun;18(6):1481-1488. (PMID: 29286569)
J Am Soc Nephrol. 2007 Jan;18(1):155-64. (PMID: 17167117)
Crit Care. 2007;11(2):R31. (PMID: 17331245)
Int J Cardiol. 2019 Dec 1;296:57-62. (PMID: 31230936)
J Am Coll Cardiol. 2012 Jan 17;59(3):246-55. (PMID: 22240130)
Pediatr Transplant. 2022 Sep;26(6):e14172. (PMID: 34668615)
Kidney Int Rep. 2016 May;1(1):3-9. (PMID: 27610421)
Pediatr Nephrol. 2016 Apr;31(4):671-8. (PMID: 26559064)
Eur J Pediatr. 2022 May;181(5):1909-1921. (PMID: 35039910)
J Am Coll Cardiol. 2009 Feb 17;53(7):589-596. (PMID: 19215833)
Kidney Int. 2011 Sep;80(6):655-62. (PMID: 21525851)
J Heart Lung Transplant. 2007 Feb;26(2):108-13. (PMID: 17258142)
Am J Kidney Dis. 2006 Nov;48(5):787-96. (PMID: 17059998)
Semin Pediatr Surg. 2021 Apr;30(2):151039. (PMID: 33992306)
Ann Card Anaesth. 2016 Oct-Dec;19(4):687-698. (PMID: 27716701)
Am J Nephrol. 2017;45(4):320-326. (PMID: 28245441)
Pediatr Transplant. 2011 Jun;15(4):430-6. (PMID: 21585631)
Semin Nephrol. 2018 Jan;38(1):3-11. (PMID: 29291759)
Int J Mol Sci. 2019 Aug 09;20(16):. (PMID: 31395800)
Kidney Int. 1995 Nov;48(5):1624-34. (PMID: 8544424)
J Am Soc Nephrol. 2009 Mar;20(3):629-37. (PMID: 19158356)
J Heart Lung Transplant. 2017 Oct 2;:. (PMID: 29055603)
Am J Kidney Dis. 2013 May;61(5):730-8. (PMID: 23332602)
Clin Transplant. 2021 Jun;35(6):e14296. (PMID: 33759249)
Am J Physiol Renal Physiol. 2007 Jul;293(1):F30-40. (PMID: 17327501)
Pediatr Neonatol. 2019 Feb;60(1):3-11. (PMID: 29891225)
J Heart Lung Transplant. 2022 Mar;41(3):356-364. (PMID: 34953720)
J Cardiothorac Vasc Anesth. 2023 Oct;37(10):2020-2026. (PMID: 37419756)
معلومات مُعتمدة: R01 DK126739 United States DK NIDDK NIH HHS; K23 DK133729 United States DK NIDDK NIH HHS; U01 DK116066 United States DK NIDDK NIH HHS; R01 MD014161 United States MD NIMHD NIH HHS; R01 DK114893 United States DK NIDDK NIH HHS; U01 DK130058 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: acute kidney injury; heart transplant; pediatrics; transplant outcomes
تواريخ الأحداث: Date Created: 20240722 Date Completed: 20240722 Latest Revision: 20240726
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11268797
DOI: 10.1111/petr.14829
PMID: 39036942
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-3046
DOI:10.1111/petr.14829