دورية أكاديمية
Isotretinoin-Induced Hypersomnia: A Cross-sectional Study and Literature Review.
العنوان: | Isotretinoin-Induced Hypersomnia: A Cross-sectional Study and Literature Review. |
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المؤلفون: | Shawky A; At Al-Azhar University, Cairo, Egypt, Ahmed Shawky, MD, is Assistant Professor, Department of Dermatology, Faculty of Medicine; Mohamed Elsheikh, MD, is Assistant Professor, Department of Psychiatry, Faculty of Medicine; Emad M. Elrewiny, MD, is Assistant Professor, Department of Dermatology, Faculty of Medicine; Mohamed Adwi, MBBCh, is General Practitioner, Faculty of Medicine; and Mahmoud A. Rageh, MD, is Lecturer, Department of Dermatology, Faculty of Medicine., Elsheikh M, Elrewiny EM, Adwi M, Rageh MA |
المصدر: | Advances in skin & wound care [Adv Skin Wound Care] 2024 Aug 01; Vol. 37 (8), pp. 1-3. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100911021 Publication Model: Print Cited Medium: Internet ISSN: 1538-8654 (Electronic) Linking ISSN: 15277941 NLM ISO Abbreviation: Adv Skin Wound Care Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2002->: [Philadelphia, Pa.?] : Lippincott Williams & Wilkins Original Publication: Springhouse, PA : Springhouse Corp., c2000- |
مواضيع طبية MeSH: | Isotretinoin*/adverse effects , Acne Vulgaris*/drug therapy , Dermatologic Agents*/adverse effects , Dermatologic Agents*/therapeutic use , Disorders of Excessive Somnolence*/chemically induced, Humans ; Cross-Sectional Studies ; Male ; Female ; Adult ; Young Adult ; Adolescent |
مستخلص: | Background: Isotretinoin is an oral retinoic drug for severe resistant acne cases that has controversially been associated with multiple psychiatric adverse effects. Research has primarily focused on depression and suicidality; however, a few case studies reported hypersomnia and sleep changes after isotretinoin initiation. Objective: To assess sleep quality and measure rates of hypersomnia, depression, and anxiety in patients undergoing isotretinoin therapy. Methods: This cross-sectional study was conducted at outpatient clinics of the university hospital. The rate of self-reported oversleeping was measured. In addition, researchers used the Pittsburgh Sleep Quality Index to assess sleep quality and conducted semistructured clinical interviews to detect depression and anxiety. Results: Of 123 patients with acne on isotretinoin, 77 (62.6%) reported oversleeping. Nearly half (60 patients, 48.8%) were categorized as poor sleepers according to the Pittsburgh Sleep Quality Index. The interviews revealed anxiety and depression percentages among 9.8% and 4.9% of participants, respectively. Conclusions: Hypersomnia was noticeably high in this study sample; thus, it may cautiously suggest a possible link between isotretinoin and hypersomnia. However, more research is needed to investigate this potential relationship. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
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المشرفين على المادة: | EH28UP18IF (Isotretinoin) 0 (Dermatologic Agents) |
تواريخ الأحداث: | Date Created: 20240722 Date Completed: 20240722 Latest Revision: 20240723 |
رمز التحديث: | 20240725 |
DOI: | 10.1097/ASW.0000000000000187 |
PMID: | 39037104 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1538-8654 |
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DOI: | 10.1097/ASW.0000000000000187 |