دورية أكاديمية
أعرض في EDS

Isotretinoin-Induced Hypersomnia: A Cross-sectional Study and Literature Review.

التفاصيل البيبلوغرافية
العنوان: Isotretinoin-Induced Hypersomnia: A Cross-sectional Study and Literature Review.
المؤلفون: Shawky A; At Al-Azhar University, Cairo, Egypt, Ahmed Shawky, MD, is Assistant Professor, Department of Dermatology, Faculty of Medicine; Mohamed Elsheikh, MD, is Assistant Professor, Department of Psychiatry, Faculty of Medicine; Emad M. Elrewiny, MD, is Assistant Professor, Department of Dermatology, Faculty of Medicine; Mohamed Adwi, MBBCh, is General Practitioner, Faculty of Medicine; and Mahmoud A. Rageh, MD, is Lecturer, Department of Dermatology, Faculty of Medicine., Elsheikh M, Elrewiny EM, Adwi M, Rageh MA
المصدر: Advances in skin & wound care [Adv Skin Wound Care] 2024 Aug 01; Vol. 37 (8), pp. 1-3.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100911021 Publication Model: Print Cited Medium: Internet ISSN: 1538-8654 (Electronic) Linking ISSN: 15277941 NLM ISO Abbreviation: Adv Skin Wound Care Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002->: [Philadelphia, Pa.?] : Lippincott Williams & Wilkins
Original Publication: Springhouse, PA : Springhouse Corp., c2000-
مواضيع طبية MeSH: Isotretinoin*/adverse effects , Acne Vulgaris*/drug therapy , Dermatologic Agents*/adverse effects , Dermatologic Agents*/therapeutic use , Disorders of Excessive Somnolence*/chemically induced, Humans ; Cross-Sectional Studies ; Male ; Female ; Adult ; Young Adult ; Adolescent
مستخلص: Background: Isotretinoin is an oral retinoic drug for severe resistant acne cases that has controversially been associated with multiple psychiatric adverse effects. Research has primarily focused on depression and suicidality; however, a few case studies reported hypersomnia and sleep changes after isotretinoin initiation.
Objective: To assess sleep quality and measure rates of hypersomnia, depression, and anxiety in patients undergoing isotretinoin therapy.
Methods: This cross-sectional study was conducted at outpatient clinics of the university hospital. The rate of self-reported oversleeping was measured. In addition, researchers used the Pittsburgh Sleep Quality Index to assess sleep quality and conducted semistructured clinical interviews to detect depression and anxiety.
Results: Of 123 patients with acne on isotretinoin, 77 (62.6%) reported oversleeping. Nearly half (60 patients, 48.8%) were categorized as poor sleepers according to the Pittsburgh Sleep Quality Index. The interviews revealed anxiety and depression percentages among 9.8% and 4.9% of participants, respectively.
Conclusions: Hypersomnia was noticeably high in this study sample; thus, it may cautiously suggest a possible link between isotretinoin and hypersomnia. However, more research is needed to investigate this potential relationship.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: EH28UP18IF (Isotretinoin)
0 (Dermatologic Agents)
تواريخ الأحداث: Date Created: 20240722 Date Completed: 20240722 Latest Revision: 20240723
رمز التحديث: 20240725
DOI: 10.1097/ASW.0000000000000187
PMID: 39037104
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-8654
DOI:10.1097/ASW.0000000000000187