دورية أكاديمية
Exploring host-pathogen interactions in the Dictyostelium discoideum-Mycobacterium marinum infection model of tuberculosis.
| العنوان: | Exploring host-pathogen interactions in the Dictyostelium discoideum-Mycobacterium marinum infection model of tuberculosis. |
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| المؤلفون: | Guallar-Garrido S; Department of Biochemistry, Faculty of Science, University of Geneva, 30 quai Ernest-Ansermet, Science II, 1211 Geneva-4, Switzerland., Soldati T; Department of Biochemistry, Faculty of Science, University of Geneva, 30 quai Ernest-Ansermet, Science II, 1211 Geneva-4, Switzerland. |
| المصدر: | Disease models & mechanisms [Dis Model Mech] 2024 Jul 01; Vol. 17 (7). Date of Electronic Publication: 2024 Jul 22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Company of Biologists Ltd., c2008- |
| مواضيع طبية MeSH: | Dictyostelium*/microbiology , Mycobacterium marinum*/pathogenicity , Host-Pathogen Interactions* , Tuberculosis*/microbiology , Tuberculosis*/pathology , Tuberculosis*/immunology, Humans ; Models, Biological ; Animals ; Mycobacterium Infections, Nontuberculous |
| مستخلص: | Mycobacterium tuberculosis is a pathogenic mycobacterium that causes tuberculosis. Tuberculosis is a significant global health concern that poses numerous clinical challenges, particularly in terms of finding effective treatments for patients. Throughout evolution, host immune cells have developed cell-autonomous defence strategies to restrain and eliminate mycobacteria. Concurrently, mycobacteria have evolved an array of virulence factors to counteract these host defences, resulting in a dynamic interaction between host and pathogen. Here, we review recent findings, including those arising from the use of the amoeba Dictyostelium discoideum as a model to investigate key mycobacterial infection pathways. D. discoideum serves as a scalable and genetically tractable model for human phagocytes, providing valuable insights into the intricate mechanisms of host-pathogen interactions. We also highlight certain similarities between M. tuberculosis and Mycobacterium marinum, and the use of M. marinum to more safely investigate mycobacteria in D. discoideum. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2024. Published by The Company of Biologists Ltd.) |
| معلومات مُعتمدة: | 310030_169386 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung |
| فهرسة مساهمة: | Keywords: Dictyostelium; Autophagy; ESCRT; Mycobacteria; Phagocytes |
| SCR Disease Name: | Infection with Mycobacterium marinum |
| تواريخ الأحداث: | Date Created: 20240722 Date Completed: 20240722 Latest Revision: 20240722 |
| رمز التحديث: | 20240722 |
| DOI: | 10.1242/dmm.050698 |
| PMID: | 39037280 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1754-8411 |
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| DOI: | 10.1242/dmm.050698 |