دورية أكاديمية
Luteolin: A promising modulator of apoptosis and survival signaling in liver cancer.
| العنوان: | Luteolin: A promising modulator of apoptosis and survival signaling in liver cancer. |
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| المؤلفون: | Rath P; Amity Institute of Environmental Sciences, Amity University, Noida 201303, India. Electronic address: prangyarath71@gmail.com., Chauhan A; Amity Institute of Environment Toxicology and Safety Management, Amity University, Noida, India. Electronic address: akchauhan@amity.edu., Ranjan A; Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia. Electronic address: aranjan@amity.edu., Aggarwal D; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar University, Ambala 133207, India. Electronic address: diwakaraggarwal@yahoo.co.in., Rani I; Department of Biochemistry, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), Sadopur, Ambala 134007, India. Electronic address: singlaisha8@gmail.com., Choudhary R; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar University, Ambala 133207, India. Electronic address: renuka.ndri@gmail.com., Shahwan M; Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates; Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates. Electronic address: moyad76@hotmail.com., Ramniwas S; University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Mohali 140413, India. Electronic address: seema.ramniwas@gmail.com., Joshi H; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address: hemantjoshibcas@gmail.com., Haque S; Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates; Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 1102 2801, Lebanon. Electronic address: shafiul.haque@hotmail.com., Mathkor DM; Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia. Electronic address: darin.mathkor@gmail.com., Tuli HS; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar University, Ambala 133207, India. Electronic address: hardeep.biotech@gmail.com. |
| المصدر: | Pathology, research and practice [Pathol Res Pract] 2024 Aug; Vol. 260, pp. 155430. Date of Electronic Publication: 2024 Jul 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fischer Verlag Original Publication: Stuttgart, New York, Fischer. |
| مواضيع طبية MeSH: | Luteolin*/pharmacology , Luteolin*/therapeutic use , Apoptosis*/drug effects , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Signal Transduction*/drug effects, Humans ; Autophagy/drug effects ; Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology |
| مستخلص: | Due to the increasing incidence of cancer and the difficulties in determining the safety profile of existing therapeutic approaches, cancer research has recently become heavily involved in the search for new therapeutic approaches. The therapeutic significance of natural substances, especially flavonoids, against the onset and progression of cancer has been emphasized in traditional food-based medicine. Interestingly, the flavone luteolin possesses biological effects that have been linked to its anti-inflammatory, antioxidant, and anticancer effects. Luteolin interacts with several downstream chemicals and signaling pathways, including those involved in apoptosis, autophagy, cell cycle progression, and angiogenesis, to exert its anticancer effects on various cancerous cells. A complete understanding of both intrinsic and extrinsic apoptotic pathways, autophagy, and, most critically, the nanodelivery of luteolin in liver cancer is provided in the current review. Competing Interests: Declaration of Competing Interest The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. (Copyright © 2024 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Apoptosis; Autophagy; Drug delivery; Liver cancer; Luteolin |
| المشرفين على المادة: | KUX1ZNC9J2 (Luteolin) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20240722 Date Completed: 20240807 Latest Revision: 20240807 |
| رمز التحديث: | 20240808 |
| DOI: | 10.1016/j.prp.2024.155430 |
| PMID: | 39038389 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-0631 |
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| DOI: | 10.1016/j.prp.2024.155430 |