دورية أكاديمية

Understanding interobserver variability of pathologists to improve oral epithelial dysplasia grading.

التفاصيل البيبلوغرافية
العنوان: Understanding interobserver variability of pathologists to improve oral epithelial dysplasia grading.
المؤلفون: Ng GTE; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Phang SC; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Yu KS; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Tiwari L; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Khurram SA; Unit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK., Sloan P; School of Dental Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; AMLo Biosciences, Newcastle upon Tyne, UK., Kujan O; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia.
المصدر: Oral diseases [Oral Dis] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : Copenhagen, Denmark : Munksgaard
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مستخلص: Objective: This study aimed to understand reasons for interobserver variability in the grading of oral epithelial dysplasia (OED) through a survey of pathologists to provide insight for improvements in the reliability and reproducibility of OED diagnoses.
Methods: The study design included quantitative and qualitative methodology. A pre-validated 31-item questionnaire was distributed to general, head and neck, and oral and maxillofacial histopathology specialists worldwide.
Results: A total of 132 pathologists participated and completed the questionnaire. Over two-thirds used the three-tier grading system for OED, while about a third used both binary and three-tier systems. Regular reporters of OED preferred the three-tier system and grading architectural features. Continuing education significantly aided recognition of architectural and cytological changes. Irregular epithelial stratification and drop-shaped rete ridges had the lowest prognostic value and recognition scores, while loss of epithelial cell cohesion had the highest. Most participants used clinical information and often sought a second opinion when grading OED.
Conclusion: Our study has found that frequency of OED reporting and attendance of CME/CPD can play an important role in grading OED. Variations in the prognostic value of individual histological features and the use of clinical information may further contribute to interobserver variability.
(© 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd.)
References: Abbey, L. M., Kaugars, G. E., Gunsolley, J. C., Burns, J. C., Page, D. G., Svirsky, J. A., Eisenberg, E., Krutchkoff, D. J., & Cushing, M. (1995). Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 80(2), 188–191.
De Vet, H. C. W., Knipschild, P. G., Schouten, H. J. A., Koudstaal, J., Kwee, W.‐S., Willebrand, D., Sturmans, F., & Arends, J. W. (1992). Sources of interobserver variation in histopathological grading of cervical dysplasia. Journal of Clinical Epidemiology, 45(7), 785–790. https://doi.org/10.1016/0895‐4356(92)90056‐S.
Dost, F., Lê Cao, K., Ford, P. J., Ades, C., & Farah, C. S. (2014). Malignant transformation of oral epithelial dysplasia: A real‐world evaluation of histopathologic grading. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 117(3), 343–352. https://doi.org/10.1016/j.oooo.2013.09.017.
Elmore, J. G., Barnhill, R. L., Elder, D. E., Longton, G. M., Pepe, M. S., Reisch, L. M., Carney, P. A., Titus, L. J., Nelson, H. D., Onega, T., Tosteson, A. N. A., Weinstock, M. A., Knezevich, S. R., & Piepkorn, M. W. (2017). Pathologists' diagnosis of invasive melanoma and melanocytic proliferations: Observer accuracy and reproducibility study. BMJ, 357, j2813. https://doi.org/10.1136/bmj.j2813.
El‐Sakka, H., Kujan, O., & Farah, C. S. (2018). Assessing miRNAs profile expression as a risk stratification biomarker in oral potentially malignant disorders: A systematic review. Oral Oncology, 77, 57–82. https://doi.org/10.1016/j.oraloncology.2017.11.021.
Eysenbach, G. (2004). Improving the quality of web surveys: The checklist for reporting results of internet E‐surveys (CHERRIES). Journal of Medical Internet Research, 6(3), e34. https://doi.org/10.2196/jmir.6.3.e34.
Geetha, K. M., Leeky, M., Narayan, T. V., Sadhana, S., & Saleha, J. (2015). Grading of oral epithelial dysplasia: Points to ponder. Journal of Oral and Maxillofacial Pathology, 19(2), 198–204. https://doi.org/10.4103/0973‐029X.164533.
Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell, 144(5), 646–674.
Kallarakkal, T. G., Zaini, Z. M., Ghani, W. M. N., Karen‐Ng, L. P., Siriwardena, B., Cheong, S. C., & Tilakaratne, W. M. (2024). Calibration improves the agreement in grading oral epithelial dysplasia‐findings from a National Workshop in Malaysia. Journal of Oral Pathology & Medicine, 53(1), 53–60. https://doi.org/10.1111/jop.13501.
Karabulut, A., Reibel, J., Therkildsen, M. H., Praetorius, F., Nielsen, H. W., & Dabelsteen, E. (1995). Observer variability in the histologic assessment of oral premalignant lesions. Journal of Oral Pathology & Medicine, 24(5), 198–200. https://doi.org/10.1111/j.1600‐0714.1995.tb01166.x.
Krishnan, L., Karpagaselvi, K., Kumarswamy, J., Sudheendra, U. S., Santosh, K. V., & Patil, A. (2016). Inter‐ and intra‐observer variability in three grading systems for oral epithelial dysplasia. Journal of Oral and Maxillofacial Pathology, 20(2), 261–268. https://doi.org/10.4103/0973‐029X.185928.
Krutchkoff, D. J., Eisenberg, E., & Anderson, C. (1991). Dysplasia of oral mucosa: A unified approach to proper evaluation. Modern Pathology, 4(1), 113–119.
Kujan, O., Idrees, M., Anand, N., Soh, B., Wong, E., & Farah, C. S. (2021). Efficacy of oral brush cytology cell block immunocytochemistry in the diagnosis of oral leukoplakia and oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 50(5), 451–458. https://doi.org/10.1111/jop.13153.
Kujan, O., Khattab, A., Oliver, R. J., Roberts, S. A., Thakker, N., & Sloan, P. (2007). Why oral histopathology suffers inter‐observer variability on grading oral epithelial dysplasia: An attempt to understand the sources of variation. Oral Oncology, 43(3), 224–231. https://doi.org/10.1016/j.oraloncology.2006.03.009.
Kujan, O., Oliver, R. J., Khattab, A., Roberts, S. A., Thakker, N., & Sloan, P. (2006). Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation. Oral Oncology, 42(10), 987–993. https://doi.org/10.1016/j.oraloncology.2005.12.014.
Kujan, O., Siddiqui, I., Lee, C., Idrees, M., Shearston, K., & Farah, C. S. (2023). Automated immunohistochemical quantification of hypoxia biomarkers shows correlation with dysplastic epithelial changes. Journal of Oral Pathology & Medicine, 52(6), 504–513. https://doi.org/10.1111/jop.13427.
Lingen, M., Vigneswaran, N., Kujan, O., Kurgo, Z. B., Poh, C., & Ranganathan, K. (Eds.). (2023). Chapter XX: Oral epithelial dysplasia. In WHO classification of Tumours editorial board. Head and neck tumours. WHO classification of tumours series (Vol. 9, 5th ed.). International Agency for Research on Cancer. https://publications.iarc.who.int/629.
Mahmood, H., Bradburn, M., Rajpoot, N., Islam, N. M., Kujan, O., & Khurram, S. A. (2022). Prediction of malignant transformation and recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models. Modern Pathology, 35(9), 1151–1159. https://doi.org/10.1038/s41379‐022‐01067‐x.
Manchanda, A., & Shetty, D. C. (2012). Reproducibility of grading systems in oral epithelial dysplasia. Medicina Oral, Patología Oral y Cirugía Bucal, 17(6), e935–e942. https://doi.org/10.4317/medoral.17749.
Morais, E. F., Pinheiro, J. C., Lira, J. A., Mafra, R. P., Barboza, C. A., Souza, L. B., & Freitas, R. D. (2020). Prognostic value of the immunohistochemical detection of epithelial‐mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review. Medicina Oral, Patología Oral y Cirugía Bucal, 25(2), e205–e216. https://doi.org/10.4317/medoral.23305.
Muller, S., & Tilakaratne, W. M. (2022). Update from the 5th edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the oral cavity and mobile tongue. Head and Neck Pathology, 16(1), 54–62. https://doi.org/10.1007/s12105‐021‐01402‐9.
Nankivell, P., Williams, H., Matthews, P., Suortamo, S., Snead, D., McConkey, C., & Mehanna, H. (2013). The binary oral dysplasia grading system: Validity testing and suggested improvement. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 115(1), 87–94. https://doi.org/10.1016/j.oooo.2012.10.015.
Odell, E., Kujan, O., Warnakulasuriya, S., & Sloan, P. (2021). Oral epithelial dysplasia: Recognition, grading and clinical significance. Oral Diseases, 27(8), 1947–1976. https://doi.org/10.1111/odi.13993.
Ranganathan, K., & Kavitha, L. (2019). Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. Journal of Oral and Maxillofacial Pathology, 23(1), 19–27. https://doi.org/10.4103/jomfp.JOMFP_13_19.
Ranganathan, K., Kavitha, L., Sharada, P., Bavle, R. M., Rao, R. S., Pattanshetty, S. M., Hazarey, V. K., Madhura, M. G., Nagaraj, T., Lingappa, A., & Warnakulasuriya, S. (2020). Intra‐observer and inter‐observer variability in two grading systems for oral epithelial dysplasia: A multi‐centre study in India. Journal of Oral Pathology & Medicine, 49(9), 948–955. https://doi.org/10.1111/jop.13056.
Reibel, J. (2003). Prognosis of oral pre‐malignant lesions: Significance of clinical, histopathological, and molecular biological characteristics. Critical Reviews in Oral Biology and Medicine, 14(1), 47–62.
Sathasivam, H. P., Sloan, P., Thomson, P. J., & Robinson, M. (2022). The clinical utility of contemporary oral epithelial dysplasia grading systems. Journal of Oral Pathology & Medicine, 51(2), 180–187. https://doi.org/10.1111/jop.13262.
Speight, P. M., Abram, T. J., Floriano, P. N., James, R., Vick, J., Thornhill, M. H., Murdoch, C., Freeman, C., Hegarty, A. M., D'Apice, K., Kerr, A. R., Phelan, J., Corby, P., Khouly, I., Vigneswaran, N., Bouquot, J., Demian, N. M., Weinstock, Y. E., Redding, S. W., … McDevitt, J. T. (2015). Interobserver agreement in dysplasia grading: Toward an enhanced gold standard for clinical pathology trials. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 120(4), 474–482.e2. https://doi.org/10.1016/j.oooo.2015.05.023.
Speight, P. M., Khurram, S. A., & Kujan, O. (2018). Oral potentially malignant disorders: Risk of progression to malignancy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 125(6), 612–627. https://doi.org/10.1016/j.oooo.2017.12.011.
فهرسة مساهمة: Keywords: grading; interobserver variability; intra‐observer; oral epithelial dysplasia; survey
تواريخ الأحداث: Date Created: 20240723 Latest Revision: 20240723
رمز التحديث: 20240723
DOI: 10.1111/odi.15078
PMID: 39039698
قاعدة البيانات: MEDLINE
الوصف
تدمد:1601-0825
DOI:10.1111/odi.15078