دورية أكاديمية
أعرض في EDS

Puerarin inhibits Staphylococcus aureus-induced endometritis through attenuating inflammation and ferroptosis via regulating the P2X7/NLRP3 signalling pathway.

التفاصيل البيبلوغرافية
العنوان: Puerarin inhibits Staphylococcus aureus-induced endometritis through attenuating inflammation and ferroptosis via regulating the P2X7/NLRP3 signalling pathway.
المؤلفون: Yuan C; Department of Obstetrics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China., Liu L; Reproductive Medicine Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China., Zhao Y; Department of Dermatological, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China., Wang K; Department of Obstetrics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Jul; Vol. 28 (14), pp. e18550.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Bucharest : "Carol Davila" University Press, 2000-
مواضيع طبية MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Isoflavones*/pharmacology , Isoflavones*/therapeutic use , Ferroptosis*/drug effects , Staphylococcus aureus*/pathogenicity , Endometritis*/metabolism , Endometritis*/microbiology , Endometritis*/drug therapy , Endometritis*/pathology , Signal Transduction*/drug effects , Receptors, Purinergic P2X7*/metabolism , Staphylococcal Infections*/metabolism , Staphylococcal Infections*/microbiology , Staphylococcal Infections*/drug therapy, Animals ; Female ; Mice ; Inflammation/metabolism ; Inflammation/pathology ; Uterus/metabolism ; Uterus/pathology ; Uterus/drug effects ; Uterus/microbiology ; Oxidative Stress/drug effects
مستخلص: Endometritis is one of the important causes of infertility. Puerarin (PU) can inhibit oxidative stress and reduce inflammation; however, it is unclear whether PU has a protective effect on the endometritis. In our study, we used Staphylococcus aureus to induce mouse endometritis. The PU group (100 mg/kg PU) and the S. aureus + PU group received daily intraperitoneal injection of PU (25, 50 or 100 mg/kg PU). The results showed that S. aureus significantly increased the levels of MPO, TNF-α, IL-1β and IL-6 in uterine tissue, and increased the expression of p-p65 and p-IκBα proteins in uterine tissue to induce endometritis in mice (p < 0.05). Furthermore, it has been found that S. aureus promotes the occurrence of ferroptosis by reducing GSH and ATP content, increasing MDA and iron content and reducing GPX4 and SLC7A11 protein expression levels (p < 0.05). S. aureus significantly increase the expression of NLRP3, ASC, caspase-1 and P2X7 proteins in uterine tissue (p < 0.05). However, PU obviously reduced the inflammatory response and reversed the changes of ferroptosis and the expression of P2X7 receptor/NLRP3 pathway associated proteins of the uterus induced by S. aureus (p < 0.05). Taken together, these findings emphasize the protective effect of PU on endometritis by regulating the P2X7 receptor/NLRP3 signalling pathway and inhibiting ferroptosis.
(© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: NLRP3; P2X7; endometritis; ferroptosis; puerarin
المشرفين على المادة: 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Isoflavones)
Z9W8997416 (puerarin)
0 (Receptors, Purinergic P2X7)
0 (Nlrp3 protein, mouse)
تواريخ الأحداث: Date Created: 20240723 Date Completed: 20240723 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11265464
DOI: 10.1111/jcmm.18550
PMID: 39042561
قاعدة البيانات: MEDLINE
الوصف
تدمد:1582-4934
DOI:10.1111/jcmm.18550