دورية أكاديمية
أعرض في EDS

Geographic Distribution of Rabies Virus and Genomic Sequence Alignment of Wild and Vaccine Strains, Kenya.

التفاصيل البيبلوغرافية
العنوان: Geographic Distribution of Rabies Virus and Genomic Sequence Alignment of Wild and Vaccine Strains, Kenya.
المؤلفون: Wambugu EN, Kimita G, Kituyi SN, Washington MA, Masakhwe C, Mutunga LM, Jaswant G, Thumbi SM, Schaefer BC, Waitumbi JN
المصدر: Emerging infectious diseases [Emerg Infect Dis] 2024 Aug; Vol. 30 (8), pp. 1642-1650.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
مواضيع طبية MeSH: Rabies virus*/genetics , Rabies virus*/immunology , Rabies virus*/classification , Rabies*/epidemiology , Rabies*/veterinary , Rabies*/virology , Rabies*/prevention & control , Rabies Vaccines*/immunology , Rabies Vaccines*/administration & dosage , Phylogeny* , Genome, Viral*, Animals ; Kenya/epidemiology ; Dogs ; Sequence Alignment ; Humans ; Phylogeography
مستخلص: Rabies, a viral disease that causes lethal encephalitis, kills ≈59,000 persons worldwide annually, despite availability of effective countermeasures. Rabies is endemic in Kenya and is mainly transmitted to humans through bites from rabid domestic dogs. We analyzed 164 brain stems collected from rabid animals in western and eastern Kenya and evaluated the phylogenetic relationships of rabies virus (RABV) from the 2 regions. We also analyzed RABV genomes for potential amino acid changes in the vaccine antigenic sites of nucleoprotein and glycoprotein compared with RABV vaccine strains commonly used in Kenya. We found that RABV genomes from eastern Kenya overwhelmingly clustered with the Africa-1b subclade and RABV from western Kenya clustered with Africa-1a. We noted minimal amino acid variances between the wild and vaccine virus strains. These data confirm minimal viral migration between the 2 regions and that rabies endemicity is the result of limited vaccine coverage rather than limited efficacy.
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فهرسة مساهمة: Keywords: Africa; Kenya; Rabies; antigenicity; diversity; geographic isolation; lyssavirus; rabies virus; viruses; whole-genome sequencing; zoonoses
المشرفين على المادة: 0 (Rabies Vaccines)
تواريخ الأحداث: Date Created: 20240723 Date Completed: 20240723 Latest Revision: 20240808
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC11286075
DOI: 10.3201/eid3008.230876
PMID: 39043404
قاعدة البيانات: MEDLINE
الوصف
تدمد:1080-6059
DOI:10.3201/eid3008.230876