دورية أكاديمية
Anemia, Iron Deficiency, and Cause-Specific Mortality: The Atherosclerosis Risk in Communities Study.
| العنوان: | Anemia, Iron Deficiency, and Cause-Specific Mortality: The Atherosclerosis Risk in Communities Study. |
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| المؤلفون: | Cannon EJ; Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA., Misialek JR; Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA., Buckley LF; Brigham and Women's Hospital, Boston, Massachusetts, USA., Aboelsaad IAF; Brigham and Women's Hospital, Boston, Massachusetts, USA., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Leister J; Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA., Pankow JS; Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA., Lutsey PL; Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA. |
| المصدر: | Gerontology [Gerontology] 2024 Jul 24, pp. 1-10. Date of Electronic Publication: 2024 Jul 24. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 7601655 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0003 (Electronic) Linking ISSN: 0304324X NLM ISO Abbreviation: Gerontology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مستخلص: | Introduction: Anemia is a risk factor for all-cause mortality in older adults. Iron deficiency may also be associated with adverse outcomes, independent of its role in causing anemia. This study tested the hypotheses that anemia, and low ferritin among non-anemic participants, were associated with all-cause and cause-specific mortality in a community-based cohort of older adults. Methods: Fasting blood was obtained from 5,070 ARIC participants (median age: 75 years) in 2011-2013. Anemia was defined by hemoglobin concentrations <12 g/dL in women and <13 g/dL in men. We classified 4,020 non-anemic participants by quartiles of plasma ferritin, measured by the SomaScan proteomics platform. Cox proportional hazards regression was used. Mortality was ascertained via phone calls with proxies as part of twice-yearly cohort follow-up, surveillance of local hospital discharge indexes, state death records, and linkage to the National Death Index. Results: Of the total participants, 21% had anemia at baseline. Over a median of 7.5 years, there were 1,147 deaths, including 357 due to cardiovascular disease (CVD), 302 to cancer, and 132 to respiratory disease. Compared to those with normal hemoglobin, participants with anemia had a higher risk of all-cause mortality (hazard ratio 1.81 [95% CI: 1.60-2.06]), and mortality due to CVD (1.77 [1.41-2.22]), cancer (1.81 [1.41-2.33]), and respiratory disease (1.72 [1.18-2.52]) in demographics-adjusted models. In fully adjusted models, associations with all-cause mortality (1.37 [1.19-1.58]) and cause-specific mortality were attenuated. In non-anemic participants, lower ferritin levels were not associated with all-cause or cause-specific mortality, though associations were observed among participants with lesser evidence of inflammation (CRP below the median level of 1.9 mg/L) and for cancer mortality in men only. Conclusion: Anemia is common among older adults and is associated with all-cause mortality, as well as mortality due to CVD, cancer, and respiratory disease. Our results do not provide evidence that iron deficiency, independent of anemia, is associated with mortality in this population. (© 2024 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Anemia; Ferritin; Iron; Mortality |
| تواريخ الأحداث: | Date Created: 20240724 Latest Revision: 20240821 |
| رمز التحديث: | 20240822 |
| DOI: | 10.1159/000539973 |
| PMID: | 39047718 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0003 |
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| DOI: | 10.1159/000539973 |