دورية أكاديمية
The effect of nalbuphine on prevention of emergence delirium in children: a systematic review with meta-analysis.
| العنوان: | The effect of nalbuphine on prevention of emergence delirium in children: a systematic review with meta-analysis. |
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| المؤلفون: | Ng KT; University of Malaya, Department of Anesthesiology, Kuala Lumpur, Malaysia. Electronic address: katingng1@gmail.com., Lim WE; University of Glasgow, Department of Anesthesiology, Glasgow, United Kingdom., Teoh WY; University of Liverpool, Department of Medicine, Liverpool, United Kingdom., Zainal Abidin MFB; University of Malaya, Department of Anesthesiology, Kuala Lumpur, Malaysia. |
| المصدر: | Brazilian journal of anesthesiology (Elsevier) [Braz J Anesthesiol] 2024 Jul 22; Vol. 74 (5), pp. 844543. Date of Electronic Publication: 2024 Jul 22. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Editora Ltda Country of Publication: Brazil NLM ID: 101624623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-2291 (Electronic) Linking ISSN: 01040014 NLM ISO Abbreviation: Braz J Anesthesiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rio de Janeiro : Elsevier Editora Ltda, 2013- |
| مستخلص: | Background: Emergence delirium remains a major postoperative concern for children undergoing surgery. Nalbuphine is a synthetic mixed agonist-antagonist opioid, which is believed to reduce the incidence of emergence delirium in children. The primary objective was to examine the effect of nalbuphine on emergence delirium in children undergoing surgery. Methods: Databases of MEDLINE, EMBASE, and CENTRAL were searched from their starting dates until April 2023. Randomized Clinical Trials (RCT) and observational studies comparing nalbuphine and control in children undergoing surgery were included. Results: Eight studies (n = 1466 patients) were eligible for inclusion of data analysis. Compared to the control, our pooled data showed that the nalbuphine group was associated with lower incidence of emergence delirium (RR = 0.38, 95% CI [0.30, 0.47], p < 0.001) and reduced postoperative pain scores (MD = -0.98, 95% CI [-1.92, -0.04], p = 0.04). Conclusions: This review showed the administration of nalbuphine is associated with significant decrease in the incidence of emergence delirium and postoperative pain scores among children undergoing surgery. However, due to limited sample size, high degree of heterogeneity and low level of evidence, future adequately powered trials are warranted to explore the efficacy of nalbuphine on emergence delirium among the pediatric population. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2024 Sociedade Brasileira de Anestesiologia. Published by Elsevier España S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Child; Emergence delirium; Nalbuphine; Nausea; Pain, postoperative; Vomiting |
| تواريخ الأحداث: | Date Created: 20240724 Latest Revision: 20240804 |
| رمز التحديث: | 20240805 |
| DOI: | 10.1016/j.bjane.2024.844543 |
| PMID: | 39048077 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2352-2291 |
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| DOI: | 10.1016/j.bjane.2024.844543 |