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Shifts in receptors during submergence of an encephalitic arbovirus.

التفاصيل البيبلوغرافية
العنوان: Shifts in receptors during submergence of an encephalitic arbovirus.
المؤلفون: Li W; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Plante JA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Lin C; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Basu H; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Plung JS; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Fan X; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Boeckers JM; Department of Neurology, F. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Oros J; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Buck TK; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Anekal PV; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; MicRoN Core, Harvard Medical School, Boston, MA, USA., Hanson WA; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Varnum H; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Wells A; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; MicRoN Core, Harvard Medical School, Boston, MA, USA., Mann CJ; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Tjang LV; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Yang P; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Reyna RA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Mitchell BM; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Shinde DP; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Walker JL; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Choi SY; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Brusic V; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Llopis PM; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; MicRoN Core, Harvard Medical School, Boston, MA, USA., Weaver SC; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Umemori H; Department of Neurology, F. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Chiu IM; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Plante KS; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA., Abraham J; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. jonathan_abraham@hms.harvard.edu.; Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. jonathan_abraham@hms.harvard.edu.; Center for Integrated Solutions in Infectious Diseases, Broad Institute of Harvard and MIT, Cambridge, MA, USA. jonathan_abraham@hms.harvard.edu.
المصدر: Nature [Nature] 2024 Aug; Vol. 632 (8025), pp. 614-621. Date of Electronic Publication: 2024 Jul 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: Encephalitis Virus, Western Equine*/classification , Encephalitis Virus, Western Equine*/metabolism , Encephalitis Virus, Western Equine*/pathogenicity , Host Specificity* , Protocadherins*/metabolism , Receptors, Virus*/metabolism, Animals ; Female ; Humans ; Male ; Mice ; Birds/metabolism ; Birds/virology ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/virology ; Encephalomyelitis, Equine/epidemiology ; Encephalomyelitis, Equine/virology ; LDL-Receptor Related Proteins/metabolism ; Neurons/metabolism ; Neurons/virology ; Phenotype ; Receptors, LDL/metabolism ; Receptors, LDL/genetics ; Viral Envelope Proteins/metabolism ; Viral Zoonoses/epidemiology ; Viral Zoonoses/virology
مستخلص: Western equine encephalitis virus (WEEV) is an arthropod-borne virus (arbovirus) that frequently caused major outbreaks of encephalitis in humans and horses in the early twentieth century, but the frequency of outbreaks has since decreased markedly, and strains of this alphavirus isolated in the past two decades are less virulent in mammals than strains isolated in the 1930s and 1940s 1-3 . The basis for this phenotypic change in WEEV strains and coincident decrease in epizootic activity (known as viral submergence 3 ) is unclear, as is the possibility of re-emergence of highly virulent strains. Here we identify protocadherin 10 (PCDH10) as a cellular receptor for WEEV. We show that multiple highly virulent ancestral WEEV strains isolated in the 1930s and 1940s, in addition to binding human PCDH10, could also bind very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), which are recognized by another encephalitic alphavirus as receptors 4 . However, whereas most of the WEEV strains that we examined bind to PCDH10, a contemporary strain has lost the ability to recognize mammalian PCDH10 while retaining the ability to bind avian receptors, suggesting WEEV adaptation to a main reservoir host during enzootic circulation. PCDH10 supports WEEV E2-E1 glycoprotein-mediated infection of primary mouse cortical neurons, and administration of a soluble form of PCDH10 protects mice from lethal WEEV challenge. Our results have implications for the development of medical countermeasures and for risk assessment for re-emerging WEEV strains.
(© 2024. The Author(s).)
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معلومات مُعتمدة: R01 MH125162 United States MH NIMH NIH HHS; R01 AI168005 United States AI NIAID NIH HHS; T32 CA009216 United States CA NCI NIH HHS; T32 GM144273 United States GM NIGMS NIH HHS; R24 AI120942 United States AI NIAID NIH HHS; R01 AI182377 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (LDL-Receptor Related Proteins)
0 (low density lipoprotein receptor-related protein 8)
0 (PCDH10 protein, human)
0 (Pcdh10 protein, mouse)
0 (Protocadherins)
0 (Receptors, LDL)
0 (Receptors, Virus)
0 (Viral Envelope Proteins)
0 (VLDL receptor)
تواريخ الأحداث: Date Created: 20240724 Date Completed: 20240814 Latest Revision: 20240822
رمز التحديث: 20240822
مُعرف محوري في PubMed: PMC11324528
DOI: 10.1038/s41586-024-07740-2
PMID: 39048821
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4687
DOI:10.1038/s41586-024-07740-2