دورية أكاديمية
أعرض في EDS

Plasma itraconazole concentrations during treatment of feline sporotrichosis.

التفاصيل البيبلوغرافية
العنوان: Plasma itraconazole concentrations during treatment of feline sporotrichosis.
المؤلفون: Pereira-Oliveira GR; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Gremião IDF; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Corrêa ML; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Caroline Dos Santos Honorato C; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Gonçalves Viana P; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Figueiredo ABF; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Boechat JS; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Guerino Dos Reis É; Biosafety Advisory, Quality Vice-Directory, The Institute of Technology on Immunobiologicals (Bio-Manguinhos), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Oliveira RVC; Laboratory of Clinical Epidemiology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., da Silva ACA; Equivalence and Pharmacokinetics Service (Sefar), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Novotny TS; Medicines Sector, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Guaraldo L; Clinical Research Laboratory on Acute Febrile Illnesses, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Pereira SA; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
المصدر: Medical mycology [Med Mycol] 2024 Aug 02; Vol. 62 (8).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Science, c1998-
مواضيع طبية MeSH: Sporotrichosis*/drug therapy , Sporotrichosis*/veterinary , Sporotrichosis*/blood , Itraconazole*/blood , Itraconazole*/pharmacokinetics , Itraconazole*/administration & dosage , Itraconazole*/therapeutic use , Cat Diseases*/drug therapy , Cat Diseases*/blood , Cat Diseases*/microbiology , Antifungal Agents*/pharmacokinetics , Antifungal Agents*/blood , Antifungal Agents*/therapeutic use , Antifungal Agents*/administration & dosage , Potassium Iodide*/therapeutic use , Potassium Iodide*/administration & dosage , Potassium Iodide*/pharmacokinetics, Animals ; Cats ; Male ; Female ; Treatment Outcome ; Drug Therapy, Combination ; Administration, Oral ; Plasma/chemistry
مستخلص: Itraconazole (ITZ) is the most used drug to treat feline sporotrichosis; however, little is known about its pharmacokinetics in cats with this mycosis. The aim of this study was to determine plasma ITZ concentrations in cats with sporotrichosis treated with ITZ as monotherapy or in combination with potassium iodide (KI). Cats diagnosed with sporotrichosis received orally ITZ (100 mg/cat/day) or combination therapy with ITZ (100 mg/cat/day) and KI (2.5-5 mg/kg/day) in the case of worsening or stagnation of the clinical condition. At each monthly visit, blood samples were collected at an interval of 4 h for analysis of trough and peak plasma ITZ concentrations by HPLC. Clinical features and laboratory parameters were evaluated during follow-up. Sixteen cats were included in the study. The median plasma ITZ concentration of all cats was 0.75 µg/mL. The median plasma ITZ concentration was 0.5 µg/mL in cats that received ITZ monotherapy (n = 12) and 1.0 µg/mL in those treated with ITZ + KI (n = 4). The clinical cure rate was 56.3% (n = 9) and the median treatment duration was 8 weeks. Nine cats (56.3%) developed adverse clinical reactions, and hyporexia was the most frequent (n = 8; 88.9%). Serum alanine aminotransferase was elevated in four cats (25%). The median plasma ITZ concentration detected in cats was considered to be therapeutic (>0.5 µg/mL) and was reached after 4 weeks of treatment. Plasma ITZ concentrations were higher in cats that received ITZ + KI compared to those treated only with ITZ, suggesting pharmacokinetic synergism between these drugs.
(© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
معلومات مُعتمدة: JCNE E-26/202.737/2019 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; CNPq; E-26/201.715/2021 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
فهرسة مساهمة: Keywords: Sporothrix; cats; itraconazole; plasma; potassium iodide
Local Abstract: [plain-language-summary] Itraconazole is the most common therapy for feline sporotrichosis, and combination therapy with potassium iodide is used in nonresponsive cases. Our study showed that all cats achieved a therapeutic plasma concentration of itraconazole, with higher levels in cats treated with the combination therapy.
المشرفين على المادة: 304NUG5GF4 (Itraconazole)
0 (Antifungal Agents)
1C4QK22F9J (Potassium Iodide)
تواريخ الأحداث: Date Created: 20240725 Date Completed: 20240807 Latest Revision: 20240807
رمز التحديث: 20240808
DOI: 10.1093/mmy/myae076
PMID: 39049454
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2709
DOI:10.1093/mmy/myae076