دورية أكاديمية
Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial.
| العنوان: | Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial. |
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| المؤلفون: | Hiensch AE; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Depenbusch J; German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT, a partnership between DKFZ and University Medical Center Heidelberg) Heidelberg, Heidelberg, Germany., Schmidt ME; German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT, a partnership between DKFZ and University Medical Center Heidelberg) Heidelberg, Heidelberg, Germany., Monninkhof EM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Pelaez M; Gipuzkoa Cancer Unit, OSID-Onkologikoa, BioGipuzkoa, Osakidetza, San Sebastian, Spain.; Universidad Europea del Atlantico, Santander, Spain., Clauss D; German Sport University Cologne, Cologne, Germany., Gunasekara N; German Sport University Cologne, Cologne, Germany., Zimmer P; TU Dortmund University, Dortmund, Germany., Belloso J; Gipuzkoa Cancer Unit, OSID-Onkologikoa, BioGipuzkoa, Osakidetza, San Sebastian, Spain., Trevaskis M; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia., Rundqvist H; Department of Laboratory Medicine, Karolinska Institutet and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden., Wiskemann J; Heidelberg University Hospital and NCT Heidelberg (a partnership between DKFZ and University Medical Center Heidelberg), Heidelberg, Germany., Müller J; Heidelberg University Hospital and NCT Heidelberg (a partnership between DKFZ and University Medical Center Heidelberg), Heidelberg, Germany., Sweegers MG; Netherlands Cancer Institute, Amsterdam, The Netherlands., Fremd C; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.; Divison of Gynecologic Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.; German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Altena R; Karolinska Institutet, Unit for Nursing, Karolinska Comprehensive Cancer Center, Breast and Sarcoma Unit, Karolinska University Hospital, Solna, Sweden., Gorecki M; Greater Poland Cancer Centre, Poznan, Poland., Bijlsma R; Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Leeuwen-Snoeks L; Diakonessenhuis Utrecht-Zeist-Doorn, Utrecht, The Netherlands., Ten Bokkel Huinink D; Alexander Monro Ziekenhuis, Bilthoven, The Netherlands., Sonke G; Netherlands Cancer Institute, Amsterdam, The Netherlands., Lahuerta A; Gipuzkoa Cancer Unit, OSID-Onkologikoa, BioGipuzkoa, Osakidetza, San Sebastian, Spain., Mann GB; Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Peter MacCallum Cancer Centre, The University of Melbourne, Victoria, Australia., Francis PA; Peter MacCallum Cancer Centre, The University of Melbourne, Victoria, Australia., Richardson G; Cabrini Research, Cabrini Health, Malvern, Victoria, Australia., Malter W; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., van der Wall E; Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Aaronson NK; Netherlands Cancer Institute, Amsterdam, The Netherlands., Senkus E; Medical University of Gdańsk, Gdańsk, Poland., Urruticoechea A; Gipuzkoa Cancer Unit, OSID-Onkologikoa, BioGipuzkoa, Osakidetza, San Sebastian, Spain., Zopf EM; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.; Cabrini Research, Cabrini Health, Malvern, Victoria, Australia., Bloch W; German Sport University Cologne, Cologne, Germany., Stuiver MM; Netherlands Cancer Institute, Amsterdam, The Netherlands., Wengstrom Y; Karolinska Institutet, Unit for Nursing, Karolinska Comprehensive Cancer Center, Breast and Sarcoma Unit, Karolinska University Hospital, Solna, Sweden., Steindorf K; German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT, a partnership between DKFZ and University Medical Center Heidelberg) Heidelberg, Heidelberg, Germany., May AM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. a.m.may@umcutrecht.nl. |
| المصدر: | Nature medicine [Nat Med] 2024 Jul 25. Date of Electronic Publication: 2024 Jul 25. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Nature Publishing Company Original Publication: New York, NY : Nature Pub. Co., [1995- |
| مستخلص: | Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life (HRQOL) are much needed for patients with metastatic breast cancer (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed the effects of exercise on fatigue and HRQOL in patients with MBC. In total, 357 patients with MBC and a life expectancy of ≥6 months but without unstable bone metastases were recruited at eight study centers across five European countries and Australia. Participants were randomly assigned (1:1) to usual care (control group, n = 179) or a 9-month supervised exercise program (exercise group, n = 178). Intervention effects on physical fatigue (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL (EORTC QLQ-C30 summary score) were determined by comparing the change from baseline to 3, 6 (primary timepoint) and 9 months between groups using mixed models for repeated measures, adjusted for baseline values of the outcome, line of treatment (first or second versus third or higher) and study center. Exercise resulted in significant positive effects on both primary outcomes. Physical fatigue was significantly lower (-5.3 (95% confidence interval (CI), -10.0 to -0.6), Bonferroni-Holm-adjusted P = 0.027; Cohen's effect size, 0.22) and HRQOL significantly higher (4.8 (95% CI, 2.2-7.4), Bonferroni-Holm-adjusted P = 0.0003; effect size, 0.33) in the exercise group than in the control group at 6 months. Two serious adverse events occurred (that is, fractures), but both were not related to bone metastases. These results demonstrate that supervised exercise has positive effects on physical fatigue and HRQOL in patients with MBC and should be recommended as part of supportive care.ClinicalTrials.gov Identifier: NCT04120298 . (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 2018/GNT1170698 Department of Health | National Health and Medical Research Council (NHMRC); 2018/GNT1170698 Department of Health | National Health and Medical Research Council (NHMRC) |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04120298 |
| تواريخ الأحداث: | Date Created: 20240725 Latest Revision: 20240725 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1038/s41591-024-03143-y |
| PMID: | 39054374 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1546-170X |
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| DOI: | 10.1038/s41591-024-03143-y |